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A14995 2-Bromo-4-isopropylaniline, 97%

CAS Number
51605-97-1
Synonyms

Stock No. Size Price ($) Quantity Availability
A14995-06 5g 62.20
A14995-14 25g 219.00
A14995-22 100g 706.00
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2-Bromo-4-isopropylaniline, 97%

MDL
MFCD00051585

Chemical Properties

Formula
C9H12BrN
Formula Weight
214.11
Boiling Point
116-118°/3mm
Density
1.350
Storage & Sensitivity
Ambient temperatures.
Solubility
Miscible with dioxane and ethoxyethanol. Immiscible with water.

Applications

2-Bromo-4-isopropylaniline is involved in the preparation of 4-(5-aryl-1, 2, 3, 6-tetrahydropyridino) pyrimidine derivatives and 4-substituted-2-anilinopyrimidine derivatives, which find application as corticotropin releasing factor (CRF) antagonists.

Notes

Incompatible with oxidizing agents.

Literature References

Cheng, C. C.; Huang, X.; Shipps Jr, G. W.; Wang, Y. S.; Wyss, D. F.; Soucy, K. A.; Jiang, C. K.; Agrawal, S.; Ferrari, E.; He, Z.; Huang, H. C. Pyridine Carboxamides: Potent Palm Site Inhibitors of HCV NS5B Polymerase. ACS Med. Chem. Lett. 2010, 1 (9), 466-471.

Kumagai, T.; Okubo, T.; Kataoka-Okubo, H.; Chaki, S.; Okuyama, S.; Nakazato, A. Synthesis and structure-affinity relationships of 4-(5-Aryl-1,2,3,6-tetrahydropyridino)pyrimidine derivatives as corticotropin-releasing factor1 receptor antagonists. Bioorg. Med. Chem. 2001, 9 (5), 1349-1355.

GHS Hazard and Precautionary Statements

Hazard Statements: H302+H312+H332-H315-H319

Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
2638470
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2921.49
TSCA
No

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