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Ethyl diphenylphosphinite is used in the synthesis of phosphoramides.
Arbuzov reaction with alkyl halides gives diphenyl phosphine oxides, useful as Wittig-Horner intermediates. See, for example: Synthesis, 126 (1977); Tetrahedron Lett., 2433 (1979); Appendix 1.
An iminophosphorane, formed with an azido ester (Staudinger), reacts with a carboxyl group to form an amide, providing the basis of a novel peptide coupling method. The reaction occurs at lower temperatures with this reagent rather than tributyl- or triphenylphosphine: J. Org. Chem., 50, 2601 (1985). See Appendix 6.
Hazard Statements: H302-H315-H319-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant