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A15131 2,4-Dichloropyrimidine, 98+%

CAS Number
3934-20-1
Synonyms

Stock No. Size Price ($) Quantity Availability
A15131-06 5g 47.60
A15131-09 10g 70.20
A15131-18 50g 270.00
A15131-30 250g 1074.00
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2,4-Dichloropyrimidine, 98+%

MDL
MFCD00006061
EINECS
223-508-6

Chemical Properties

Formula
C4H2Cl2N2
Formula Weight
148.98
Melting point
57-62°
Boiling Point
101°/23mm
Storage & Sensitivity
Store under Nitrogen. Moisture Sensitive. Keep Cold.
Solubility
Soluble in water (partly), methanol, chloroform, and ethyl acetate.

Applications

2,4-Dichloropyrimidine is used in the synthesis of medicinally important 4-aryl-5-pyrimidinylimidazoles. It undergoes effective one-pot, regioselective double Suzuki coupling reaction to yield diarylated pyrimidines.

Notes

Moisture Sensitive. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Xiaohu Deng.; Neelakandha S. Mani. An Efficient Route to 4-Aryl-5-pyrimidinylimidazoles via Sequential Functionalization of 2,4-Dichloropyrimidine. Org. Lett. 2006, 8, (2), 269-272.

Zhi-Hui Peng.; Michel Journet.; Guy Humphrey. A Highly Regioselective Amination of 6-Aryl-2,4-dichloropyrimidine. Org. Lett. 2006, 8, (3), 395-398.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
110911
Harmonized Tariff Code
2933.59
TSCA
Yes

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