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Propiophenone is an intermediate in the synthesis of pharmaceuticals and organic compounds. It is used in the synthesis of ephedrine and propiophenone derivatives such as cathinone, and methcathinone. It can also be used in the synthesis of aryl alkenes.
Shu Kobayashi.; Satoshi Nagayama. Aldehydes vs Aldimines. Unprecedented Reactivity in Their Enolate Addition Reactions. J. Org. Chem. 1997, 62, (2), 232-233.
David P. Thomasa.; Joe P. Foley. Improved efficiency in micellar liquid chromatography using triethylamine and 1-butanol as mobile phase additives to reduce surfactant adsorption. Journal of Chromatography A. 2008, 1205, (1-2), 36-45.
Propiophenone and its derivatives are readily rearranged to methyl esters of ɑ-methyl arylacetic acids by reaction with I2, ICl or ICl3 in trimethyl orthoformate: J. Org. Chem., 53, 4859 (1988).
Undergoes a Mannich reaction with hexamethylenetetramine in acetic anhydride. The resulting ɑ-methylene derivative can be cyclized to an indanone in high yield: Synth. Commun., 26, 1775 (1996):
Hazard Statements: H227-H319
Combustible liquid. Causes serious eye irritation.
Precautionary Statements: P210-P264b-P280-P305+P351+P338-P337+P313-P370+P378q-P501c
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wash face, hands and any exposed skin thoroughly after handling Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant