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A15226 Methyl 5-nitro-2-furoate, 97%

CAS Number
1874-23-3
Synonyms
Methyl 5-nitrofuran-2-carboxylate
5-Nitrofuran-2-carboxylic acid methyl ester

Stock No. Size Price ($) Quantity Availability
A15226-06 5g 55.50
A15226-14 25g 194.00
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Methyl 5-nitro-2-furoate, 97%

MDL
MFCD00051956
EINECS
000-000-0

Chemical Properties

Formula
C6H5NO5
Formula Weight
171.11
Melting point
78-82°
Storage & Sensitivity
Ambient temperatures.

Literature References

The nitro-group is susceptible to nucleophilic displacement (compare 1,4-Dinitrobenzene, A10293): J. Heterocycl. Chem., 18, 1241 (1981). This has been used as the basis of a synthesis of diaryl ethers involving Diels-Alder addition and decarboxylative aromatization of the adduct: J. Chem. Soc., Perkin 1, 1231 (1990):

/n

Undergoes vicarious nucleophilic substitution of hydrogen at the 3-position. For example with chloromethyl phenyl sulfone and base, 2-nitro-3-(phenylsulfonylmethyl)furan is formed in 75% yield: Tetrahedron, 51, 8339 (1995). For analogous example and reaction scheme, see 2-Nitrothiophene, A17464.

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For a review of vicarious nucleophilic substitution in heterocyclic compounds, see: Synthesis, 103 (1991).

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GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
165132
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2932.19
TSCA
No
RTECS
LV2013000

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