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1874-23-3 - Methyl 5-nitro-2-furoate, 97% - Methyl 5-nitrofuran-2-carboxylate - 5-Nitrofuran-2-carboxylic acid methyl ester - A15226 - Alfa Aesar

A15226 Methyl 5-nitro-2-furoate, 97%

CAS Number
1874-23-3
Synonyms
Methyl 5-nitrofuran-2-carboxylate
5-Nitrofuran-2-carboxylic acid methyl ester

Size Price ($) Quantity Availability
5g 50.01
25g 176.02
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Methyl 5-nitro-2-furoate, 97%

MDL
MFCD00051956
EINECS
000-000-0

Chemical Properties

Formula
C6H5NO5
Formula Weight
171.11
Melting point
78-82°

Literature References

The nitro-group is susceptible to nucleophilic displacement (compare 1,4-Dinitrobenzene, A10293): J. Heterocycl. Chem., 18, 1241 (1981). This has been used as the basis of a synthesis of diaryl ethers involving Diels-Alder addition and decarboxylative aromatization of the adduct: J. Chem. Soc., Perkin 1, 1231 (1990):

/n

Undergoes vicarious nucleophilic substitution of hydrogen at the 3-position. For example with chloromethyl phenyl sulfone and base, 2-nitro-3-(phenylsulfonylmethyl)furan is formed in 75% yield: Tetrahedron, 51, 8339 (1995). For analogous example and reaction scheme, see 2-Nitrothiophene, A17464.

/n

For a review of vicarious nucleophilic substitution in heterocyclic compounds, see: Synthesis, 103 (1991).

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GHS Hazard and Precautionary Statements

Hazard Statements: H341

Suspected of causing genetic defects.

Precautionary Statements: P201-P281-P202-P308+P313-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
165132
Harmonized Tariff Code
2932.19
TSCA
No
RTECS
LV2013000

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