(1-Hexadecyl)trimethylammonium bromide is a cationic surfactant in hair conditioning products. It acts as a phase-transfer catalyst for the preparation of polyamide, polycarbonate and polythiocarbonate. It facilitates ligand-free palladium salt-catalyzed Heck and Suzuki cross-coupling reactions in water. It is an active component of the topical antiseptic cetrimide and used in household products such as shampoos and cosmetics. As a buffer solution, it is involved in the extraction of DNA as well as in the synthesis of gold nanoparticles and silican nanoparticles.
Surfactant-type catalyst (see Appendix 2) with many applications:
O-Alkylation of alcohols and phenols; see 2,6-Dimethylphenol, A11947. Surfactant-assisted permanganate oxidations: Can. J. Chem., 67, 1381 (1989). Reduction of alkyl halides to alkanes using zinc powder in micelles: Synth. Commun., 19, 1649 (1989). Control of ortho-para ratio in the bromination of anilines: Tetrahedron Lett., 30, 6209 (1989). Also facilitates ligand-free palladium salt-catalyzed Heck and Suzuki cross-coupling reactions in water: Tetrahedron Lett., 46, 3357 (2005).
Chatterjee, S.; Castro, M.; Feller, J. F. Tailoring selectivity of sprayed carbon nanotube sensors (CNT) towards volatile organic compounds (VOC) with surfactants. Food Chem. 2015, 168, 262-269.
Hazard Statements: H302-H315-H318-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye damage. May cause respiratory irritation.
Precautionary Statements: P273-P280-P305+P351+P338-P337+P313-P391-P501a
Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. Collect spillage. Dispose of contents/container in accordance with local/regional/national/international regulations.