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116-17-6 - Triisopropyl phosphite, 90+% - Phosphorous acid triisopropyl ester - A15247 - Alfa Aesar

A15247 Triisopropyl phosphite, 90+%

CAS Number
116-17-6
Synonyms
Phosphorous acid triisopropyl ester

Size Price ($) Quantity Availability
100ml 34.92
250ml 67.28
500ml 125.60
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Triisopropyl phosphite, 90+%

MDL
MFCD00008874
EINECS
204-130-0

Chemical Properties

Formula
[(CH3)2CHO]3P
Formula Weight
208.24
Boiling Point
63-64°/11mm
Flash Point
46°(114°F)
Density
0.908
Refractive Index
1.4110
Sensitivity
Air & Moisture Sensitive

Literature References

Reagent for the preparation of phosphonate esters by the Arbuzov reaction; cf Triethyl­ phosphite, L00339. Has the advantage over primary phosphites that the bulky alkyl groups minimize the product of self-alkylation. For an example (diisopropyl methanephosphonate), see: Org. Synth. Coll., 4, 325 (1963).

/n

Convenient means of introduction of an isopropyl group into an aromatic ring by Friedel-Crafts alkylation. Using nitromethane as solvent, rearrangement of existing groups can be avoided: Synthesis, 423 (1972).

/n

The complex with CuCl, the "Moser" catalyst, promotes the cyclopropanation of alkenes by diazoalkanes: J. Am. Chem. Soc., 91, 1135 (1969). For comparison with other catalysts, see: Synthesis, 787 (1981).

/n

The combination with Pd(OAc)2 is reported to be an efficient catalyst system for cross-coupling of arylboronic acids with both aryl bromides and chlorides: Chem. Eur. J., 6, 1830 (2000).

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GHS Hazard and Precautionary Statements

Hazard Statements: H301-H315-H319-H335-H226

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Flammable liquid and vapour.

Precautionary Statements: P280h-P305+P351+P338

Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Other References

Beilstein
1701528
Hazard Class
3
Packing Group
III
Harmonized Tariff Code
2920.90
TSCA
Yes
RTECS
TH2800000

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