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4-(Trifluoromethyl)benzaldehyde is useful reagent in kinetic studies of the asymmetric synthesis of alcohols and of the Wittig reaction. It is also used as Pharmaceutical intermediates.
Raymond J. Abraham; Simone Angioloni; Mark Edgar and Fernando Sancassan. Conformational analysis. Part 29.1 The conformationalanalysis of 2-substituted fluoro- and trifluoromethyl-benzaldehydes,acetophenones and methyl benzoates by the lanthanide induced shift(LIS)technique.J. Chem. Soc., Perkin Trans. 2.1997, 41-48.
D C Anderson and F W Dahlquist. Determination of the equilibrium distribution between alcohol and aldehyde substrates when bound to horse liver alcohol dehydrogenase using magnetic resonance.Biochemistry (Washington).1980, 19, (24), 5486-5493 .
Hazard Statements: H227-H315-H319-H320-H335
Combustible liquid. Causes skin irritation. Causes serious eye irritation. Causes eye irritation. May cause respiratory irritation.
Precautionary Statements: P210-P235-P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P370+P378q-P501c
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep cool. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant