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4-(Trifluoromethyl)benzaldehyde is useful reagent in kinetic studies of the asymmetric synthesis of alcohols and of the Wittig reaction. It is also used as Pharmaceutical intermediates.
Raymond J. Abraham; Simone Angioloni; Mark Edgar and Fernando Sancassan. Conformational analysis. Part 29.1 The conformationalanalysis of 2-substituted fluoro- and trifluoromethyl-benzaldehydes,acetophenones and methyl benzoates by the lanthanide induced shift(LIS)technique.J. Chem. Soc., Perkin Trans. 2.1997, 41-48.
D C Anderson and F W Dahlquist. Determination of the equilibrium distribution between alcohol and aldehyde substrates when bound to horse liver alcohol dehydrogenase using magnetic resonance.Biochemistry (Washington).1980, 19, (24), 5486-5493 .
Hazard Statements: H227-H302-H315-H319-H335
Combustible liquid. Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P280h-P305+P351+P338
Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.