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3-Nitrophenol is used as indicator in 0.3% Soln in 50% alcohol ph: 6.8 Colorless, 8.6 Yellow. It is used in the synthesis of RAGE inhibitors via the etherification of phenols. Also used in the synthesis of kinase inhibitors against epidermal growth factor receptor T790M mutation.
A. Alif; P. Boule; J. Lemaire. Photochemistry and environment XII: Phototransformation of 3-nitrophenol in aqueous solution.Journal of Photochemistry and Photobiology A.1990, 50 331-342.
Mohammad R.Haghighi Podeh; Sanjoy K. Bhattacharya; Mingbo Qu. Effects of nitrophenols on acetate utilizing methanogenic systems.Water Research.1995, 29 391-399.
Acid-base indicator: approx pH 6.6 - 8.6.
Has been used for the formation of active esters. These are more stable than the corresponding 4-nitrophenyl esters, but are sufficiently reactive for use in peptide synthesis: Synthesis, 465 (1979).
Hazard Statements: H302-H312-H315-H318-H335-H373
Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. Causes serious eye damage. May cause respiratory irritation. May cause damage to organs through prolonged or repeated exposure.
Precautionary Statements: P260-P280-P305+P351+P338-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.