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N,N-Dimethylformamide dimethyl acetal is used as an intermediate in the formation of pyridine derivatives, which exhibits inhibition against PI3 kinase p110alfa enzymes. It is utilized for the derivatization of primary sulfonamides and trifluoroacetic acid. It is also used in the preparation of formamidine derivatives. It is used as a reagent for n-dimethylaminomethylene and methyl esters. Further, it is used to catalyze the coupling of epoxides with carbon dioxide to prepare cyclic carbonates.
Lee, H. J.; Lee, S.; Yu, J.; Kim, J. N. Vinylogous N,N-dimethylaminomethylenation of 3-[(1-substituted) ethylidene]-oxindoles with N,N-dimethylformamide dimethylacetal. Tetrahedron Lett. 2014, 55 (15), 2450-2454.
Prek, B.; Grošelj, U.; Kasunič, M.; Zupančič, S.; Svete, J.; Stanovnik, B. Reactions of Methyl Ketones and (Hetero)arylcarboxamides with N, N-Dimethylacetamide Dimethyl Acetal. A Simple Metal-Free Synthesis of 2, 4, 6-Trisubstituted Pyridines. Aust. J. Chem. 2015, 68 (2), 184-195.
Hazard Statements: H225-H317-H318-H332-H361
Highly flammable liquid and vapour. May cause an allergic skin reaction. Causes serious eye damage. Harmful if inhaled. Suspected of damaging fertility or the unborn child.
Precautionary Statements: P201-P202-P210-P233-P240-P241-P242-P243-P261-P271-P272-P280g-P281-P303+P361+P353-P304+P340-P305+P351+P338-P308+P313-P310-P312-P333+P313-P363-P370+P378q-P372-P374-P380-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Avoid breathing dust/fume/gas/mist/vapours/spray. Use only outdoors or in a well-ventilated area. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves. Use personal protective equipment as required. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Immediately call a POISON CENTER or doctor/physician. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation or rash occurs: Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Explosion risk in case of fire. Fight fire with normal precautions from a reasonable distance. Evacuate area. Dispose of contents/ container to an approved waste disposal plant