Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

4637-24-5 - N,N-Dimethylformamide dimethyl acetal, 97% - 1,1-Dimethoxy-N,N-dimethylmethylamine - A15350 - Alfa Aesar

A15350 N,N-Dimethylformamide dimethyl acetal, 97%

CAS Number
4637-24-5
Synonyms
1,1-Dimethoxy-N,N-dimethylmethylamine

Size Price ($) Quantity Availability
25g 34.74
100g 98.26
500g 340.20
Add to Cart Add to Quote Request View Item

N,N-Dimethylformamide dimethyl acetal, 97%

MDL
MFCD00008482
EINECS
225-063-3

Chemical Properties

Formula
(CH3)2NCH(OCH3)2
Formula Weight
119.16
Melting point
-85°
Boiling Point
102-104°
Flash Point
7°(45°F)
Density
0.897
Refractive Index
1.3972
Sensitivity
Moisture Sensitive
Solubility
Miscible with most organic solvents.

Applications

N,N-Dimethylformamide dimethyl acetal is used as an intermediate in the formation of pyridine derivatives, which exhibits inhibition against PI3 kinase p110alfa enzymes. It is utilized for the derivatization of primary sulfonamides and trifluoroacetic acid. It is also used in the preparation of formamidine derivatives. It is used as a reagent for n-dimethylaminomethylene and methyl esters. Further, it is used to catalyze the coupling of epoxides with carbon dioxide to prepare cyclic carbonates.

Notes

Moisture sensitive. Incompatible with strong oxidizing agents and acids.

Literature References

Lee, H. J.; Lee, S.; Yu, J.; Kim, J. N. Vinylogous N,N-dimethylaminomethylenation of 3-[(1-substituted) ethylidene]-oxindoles with N,N-dimethylformamide dimethylacetal. Tetrahedron Lett. 2014, 55 (15), 2450-2454.

Prek, B.; Grošelj, U.; Kasunič, M.; Zupančič, S.; Svete, J.; Stanovnik, B. Reactions of Methyl Ketones and (Hetero)arylcarboxamides with N, N-Dimethylacetamide Dimethyl Acetal. A Simple Metal-Free Synthesis of 2, 4, 6-Trisubstituted Pyridines. Aust. J. Chem. 2015, 68 (2), 184-195.

GHS Hazard and Precautionary Statements

Hazard Statements: H225-H302-H332-H315-H319-H335

Highly flammable liquid and vapour. Harmful if swallowed. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P210-P261-P280-P240-P303+P361+P353-P305+P351+P338-P304+P340-P362-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Hazard Class
3
Packing Group
II
Harmonized Tariff Code
2911.00
TSCA
Yes

Recommended

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware