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459-57-4 - 4-Fluorobenzaldehyde, 98% - A15383 - Alfa Aesar

A15383 4-Fluorobenzaldehyde, 98%

CAS Number
459-57-4
Synonyms

Size Price ($) Quantity Availability
25g 31.93
100g 85.18
500g 339.99
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4-Fluorobenzaldehyde, 98%

MDL
MFCD00003378
EINECS
207-293-6

Chemical Properties

Formula
C7H5FO
Formula Weight
124.11
Melting point
-10°
Boiling Point
180-181°
Flash Point
56°(133°F)
Density
1.175
Refractive Index
1.5210
Sensitivity
Air Sensitive
Solubility
Immiscible with water.

Applications

4-Fluorobenzaldehyde is used in the preparation of pyrazolopyridine derivative, which finds application as mitogen-activated protein kinase (MAPK) inhibitor. It also serves as a synthetic intermediate in the preparation of pharmaceutical compounds.

Notes

Air sensitive. Incompatible with strong bases, strong oxidizing agents and strong reducing agents.

Literature References

For a facile route to 4-aryloxy phenols (Cu catalyzed substitution then Baeyer-Villiger reaction) see: Synthesis, 63 (1991). Ketones behave similarly.

Dar, B. A.; Pandey, N.; Singh, S.; Bamezai, R. K.; Sharma, M.; Vishwakarma, R. A.; Singh, B. Heterogeneous reusable catalyst, ultrasound energy, and no solvent: a quick and green recipe for one-pot synthesis of beta-phosphonomalononitriles at room temperature. Tetrahedron Lett. 2014, 53 (3), 623-628.

Barbuceanu, S. F.; Draghici, C.; Barbuceanu, F.; Bancescu, G.; Saramet, G. Design, Synthesis, Characterization and Antimicrobial Evaluation of Some Heterocyclic Condensed Systems with Bridgehead Nitrogen from Thiazolotriazole Class. Chem. Pharm. Bull. 2014, 63 (9), 694-700.

GHS Hazard and Precautionary Statements

Hazard Statements: H226-H315-H319-H335

Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P210-P261-P280-P240-P303+P361+P353-P305+P351+P338-P304+P340-P362-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
385857
Hazard Class
3
Packing Group
III
Harmonized Tariff Code
2913.00
TSCA
Yes

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