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305-01-1 - 6,7-Dihydroxycoumarin, 98+% - Cichorigenin - Esculetin - A15393 - Alfa Aesar

A15393 6,7-Dihydroxycoumarin, 98+%

CAS Number
305-01-1
Synonyms
Cichorigenin
Esculetin

Size Price ($) Quantity Availability
1g 48.20
5g 180.25
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6,7-Dihydroxycoumarin, 98+%

MDL
MFCD00006874
EINECS
206-161-5

Chemical Properties

Formula
C9H6O4
Formula Weight
178.15
Melting point
ca 270° dec.
Solubility
Soluble in DMSO, DMF, diluted alkalies with blue fluorescence, and acetone. Slightly soluble in water. Insoluble in ether. Moderately soluble in Glacial acetic acid, and hot ethanol.

Applications

In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agents.

Literature References

Neichi Tomohiro; Koshihara Yasuko; Murota Sei-Itsu. Inhibitory effect of esculetin on 5-lipoxygenase and leukotriene biosynthesis. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1983, 753 (1), 130-132.

Chia-Yih Chu; Yu-Ying Tsai; Chau-Jong Wang; Wei-Long Lin; Tsui-Hwa Tseng. Induction of apoptosis by esculetin in human leukemia cells. European Journal of Pharmacology. 2001, 416 (1-2), 25-32.

Ultraviolet absorbent.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,3697
Beilstein
152788
Harmonized Tariff Code
2932.20
TSCA
No
RTECS
GN6382500

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