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In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.
Neichi Tomohiro; Koshihara Yasuko; Murota Sei-Itsu. Inhibitory effect of esculetin on 5-lipoxygenase and leukotriene biosynthesis. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1983, 753 (1), 130-132.
Chia-Yih Chu; Yu-Ying Tsai; Chau-Jong Wang; Wei-Long Lin; Tsui-Hwa Tseng. Induction of apoptosis by esculetin in human leukemia cells. European Journal of Pharmacology. 2001, 416 (1-2), 25-32.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P260-P201-P280g-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.