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569-58-4 - Aluminon - Aurintricarboxylic acid triammonium salt - A15401 - Alfa Aesar

A15401 Aluminon

CAS Number
569-58-4
Synonyms
Aurintricarboxylic acid triammonium salt

Size Price ($) Quantity Availability
10g 18.75
50g 60.26
250g 229.04
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Aluminon

MDL
MFCD00040925
EINECS
209-319-1

Chemical Properties

Formula
C22H23N3O9
Formula Weight
473.44
Melting point
220-225° dec.
Solubility
Soluble in water(800g/L).

Applications

It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

R G González,; R S Haxo,; T Schleich. Mechanism of action of polymeric aurintricarboxylic acid, a potent inhibitor of protein--nucleic acid interactions. Biochemistry (Washington). 1980, 19 (18),4299-4303.

Y Benchokroun,; J Couprie,; A K Larsen. Aurintricarboxylic acid, a putative inhibitor of apoptosis, is a potent inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells. Biochemical Pharmacology. 1995, 49(3), 305-313.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319

Causes skin irritation. Causes serious eye irritation.

Precautionary Statements: P280-P264-P305+P351+P338-P362-P321-P332+P313-P337+P313-P302+P352

Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Take off contaminated clothing and wash before reuse. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: IF ON SKIN: Wash with plenty of soap and water.

Other References

Merck
14,322
Harmonized Tariff Code
2918.99
TSCA
Yes
RTECS
GU4800000

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