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2-Cyanothioacetamide was used in the synthesis of 3,4-trans-4-aryl-3-(1-pyridinio)-1,2,3,4-tetrahydropyridine-6-thiolates and bis[6-(2-aryl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile]. 2-Cyanothioacetamide is used as a building block for 2-pyridothiones. It can be used in agrochemical, pharmaceutical and dyestuff field etc,.
Elgemeie G. E. H. ; Ali H . A. ; Eid M. M. Reaction of 2-cyanothioacetamide with α-alkylated β-diketones: synthesis of pyridine-2(1H)-thione, thieno[2,3-b]pyridine and pyrido[2,3-c]pyrazole derivatives. Journal of Chemical Research. Synopses.1993, 7 256-257.
Cyclocondensation with Benzoyl isothiocyanate, L06964 results in the formation of a pyrimidinedithiol: Chem. Ind. (London), 270 (1988):
See also Methyl isothiocyanate, A11757.
For a review on the utility of cyanothioacetamide in heterocyclic synthesis, see: Heterocycles, 24, 2023 (1986).
Hazard Statements: H302-H312-H331-H315-H319-H335
Harmful if swallowed. Harmful in contact with skin. Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.