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4-Fluorobenzylamine is used as a potassium channel blocking agent. It is used in the synthesis of new tris-iron(III) chelates of 3-hydroxy-4-pyridinone ligands. It reacts with the α- and γ-carboxyl groups of folic acid to yield 18F-labeled folate2. It is an important building block for the synthesis of 18F-labeled compounds.
Walkiria Schlindwein; Emma Waltham; John Burgess; Norman Binsted; Ana Nunes; Andreia Leite; Maria Rangel. New lipophilic 3-hydroxy-4-pyridinonate iron(III) complexes: synthesis and EXAFS structural characterisation. Dalton Transactions. 2006, 10, 1313-1321.
Jenilee Way; Frank Wuest. Fully automated synthesis of 4-[18F]fluorobenzylamine based on borohydride/NiCl2reduction. Nuclear Medicine and Biology. 2013, 40 (3), 411-416.
Hazard Statements: H227-H314-H318
Combustible liquid. Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P210u-P260u-P303+P361+P353-P305+P351+P338-P405-P501a
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.