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A15557 4-Methoxy-o-phenylenediamine, 98%

CAS Number

Stock No. Size Price ($) Quantity Availability
A15557-03 1g 37.90
A15557-06 5g 137.00
A15557-14 25g 541.00
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4-Methoxy-o-phenylenediamine, 98%


Chemical Properties

Formula Weight
Melting point
Storage & Sensitivity
Keep Cold. Air Sensitive. Store under Argon. Light Sensitive.
Soluble in dimethyl sulfoxide and methanol.


4-Methoxy-o-phenylenediamine is widely used as an intermediate in organic synthesis and pharmaceuticals. It is an important precursor for the synthesis of other heterocyclic compounds. It is used in the determination of glyoxal, methylglyoxal, and diacetyl in urine using 4-methoxy-o-phenylenediamine as a derivatizing reagent by High-performance liquid chromatography (HPLC).


Air sensitive and Hygroscopic. Incompatible with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents.

Literature References

Ojeda, A. G.; Wrobel, K.; Escobosa, A. R. C.; Sevilla, E. G.; Wrobel, K. High-performance liquid chromatography determination of glyoxal, methylglyoxal, and diacetyl in urine using 4-methoxy-o-phenylenediamine as derivatizing reagent. Anal. Biochem. 2014, 449, 52-58.

Vadagaonkar, K. S.; Kalmode, H. P.; Mrugan, K.; Chaskar, A. C. I2 catalyzed tandem protocol for synthesis of quinoxalines via sp3, sp2and sp C-H functionalization. RSC Adv. 2015, 5 (8), 5580-5590.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H312-H315-H319-H332-H335

Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation. Harmful if inhaled. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

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Harmonized Tariff Code


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