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66-22-8 - Uracil, 99+% - 2,4-Dihydroxypyrimidine - A15570 - Alfa Aesar

A15570 Uracil, 99+%

CAS Number
66-22-8
Synonyms
2,4-Dihydroxypyrimidine

Size Price ($) Quantity Availability
50g 32.32
250g 98.16
1000g 302.82
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Uracil, 99+%

MDL
MFCD00006016
EINECS
200-621-9

Chemical Properties

Formula
C4H4N2O2
Formula Weight
112.09
Melting point
ca 330°
Solubility
Soluble in water, aqueous ammonia, 1M sodium hydroxide solution and alkalies. Insoluble in ethanol and ether.

Applications

Uracil is produced by hydrolysis of nucleic acid and used in biochemical research. It serves as a allosteric regulator and coenzyme for reactions in the human body and in plants. It reacts with fluorine to get 5-fluorouracil, which is an anticancer drug. Further, it is used in drug delivery and in pharmaceuticals. In addition to this, it is used in the synthesis of caffeine and in the determination of microbial contamination of tomatoes.

Notes

Incompatible with water, air and strong oxidizing agents.

Literature References

For a review of the use of uracils as starting materials in heterocyclic synthesis, see: Adv. Het. Chem., 55, 130 (1992).

Fornaro, T.; Burini, D.; Biczysko, M.; Barone, V. Hydrogen-Bonding Effects on Infrared Spectra from Anharmonic Computations: Uracil-Water Complexes and Uracil Dimers. J. Phys. Chem. A 2015, 119 (18), 4224-4236.

Cavaleiro, A. M.; Kim, S. H.; Seppala, S.; Nielsen, M. T.; Nørholm, M. H. Accurate DNA assembly and genome engineering with optimized uracil excision cloning. ACS Synth. Biol. 2015, 4 (9), 1042-1046.

Other References

Merck
14,9850
Beilstein
606623
Harmonized Tariff Code
2933.59
TSCA
Yes
RTECS
YQ8650000

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