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It is used in the parallel solid phase synthesis of tetra substituted diethylenetriamines via selective amide alkylation and exhaustive reduction of N-acylated dipeptides.
Jacob Szmuszkovicz, et al. Benzeneacetamide amines: structurally novel non-m.mu. opioids.J. Med. Chem.,1982,25(10), 1125-1126.
Adel Nefzi, et al. Parallel solid phase synthesis of tetrasubstituted diethylenetriamines via selective amide alkylation and exhaustive reduction of N-acylated dipeptides.Tetrahedron.,1999,55(2), 335-344.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P280g-P305+P351+P338
Wear protective gloves. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.