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1-(2-Bromoethyl)-4-nitrobenzene is an electrophile used as a substrate and activator for theta class gutathione transferase (GSTT-1). It is also used as a marker in for the θ-class of glutathione S-transferases (GSTs).
M F Lopez; W F Patton; W B Sawlivich; H Erdjument-Bromage; P Barry; K Gmyrek; T Hines; P Tempst; W M Skea. A glutathione S-transferase (GST) isozyme from broccoli with significant sequence homology to the mammalian theta-class of GSTs. Biochimica et Biophysica Acta. 1994, 1205 (1), 29-38 .
P Jemth; and B Mannervik. Kinetic characterization of recombinant human glutathione transferase T1-1, a polymorphic detoxication enzyme. Archives of Biochemistry and Biophysics. 1997, 348 (2), 247-254 .
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.