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1-(2-Bromoethyl)-4-nitrobenzene is an electrophile used as a substrate and activator for theta class gutathione transferase (GSTT-1). It is also used as a marker in for the θ-class of glutathione S-transferases (GSTs).
M F Lopez; W F Patton; W B Sawlivich; H Erdjument-Bromage; P Barry; K Gmyrek; T Hines; P Tempst; W M Skea. A glutathione S-transferase (GST) isozyme from broccoli with significant sequence homology to the mammalian theta-class of GSTs. Biochimica et Biophysica Acta. 1994, 1205 (1), 29-38 .
P Jemth; and B Mannervik. Kinetic characterization of recombinant human glutathione transferase T1-1, a polymorphic detoxication enzyme. Archives of Biochemistry and Biophysics. 1997, 348 (2), 247-254 .
Hazard Statements: H315-H317-H319-H335
Causes skin irritation. May cause an allergic skin reaction. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P272-P280-P302+P352-P304+P340-P305+P351+P338-P312-P333+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation or rash occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant