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A15682 Benzyl chloroformate, 95%, stab. with ca 0.1% sodium carbonate

CAS Number
501-53-1
Synonyms
Carbobenzoxy chloride
Chloroformic acid benzyl ester

Stock No. Size Price ($) Quantity Availability
A15682-18 50g 40.50
A15682-30 250g 173.00
A15682-0B 1000g 612.00
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Benzyl chloroformate, 95%, stab. with ca 0.1% sodium carbonate

MDL
MFCD00000640
EINECS
207-925-0

Chemical Properties

Formula
C8H7ClO2
Formula Weight
170.60
Melting point
-20°
Boiling Point
178-180°
Flash Point
125°(257°F)
Density
1.195
Refractive Index
1.5170
Storage & Sensitivity
Store at -20°C. Moisture Sensitive.
Solubility
Miscible with ether, acetone and benzene.

Applications

Benzyl chloroformate is widely used as a reactive chemical intermediate in plastic, pharmaceutical, agricultural and organic chemicals. It is useful for the introduction of carboxybenzyl (cbz) protecting group for amines such as aniline in organic synthesis. It is also involved in the synthesis of 1,2,4-oxadiazoles.

Notes

Store in cool place. Moisture sensitive.

Literature References

Kim, J. S.; Kang, J. C.; Yoo, G. H.; Jin, X.; Myeong, I. S.; Oh, C. Y.; Ham, W. H. Stereoselective total synthesis of (-)-conduramine F-1 via chiral 1,3-oxazine. Tetrahedron 2015, 71 (18), 2772-2776.

Lezama, J.; Domínguez, R. M.; Chuchani, G. Kinetics of the Gas-Phase Elimination Reaction of Benzyl Chloroformate and Neopentyl Chloroformate. Int. J. Chem. Kinet. 2015, 47 (2), 104-112.

GHS Hazard and Precautionary Statements

Hazard Statements: H227-H290-H303-H314-H332-H335-H336-H350-H373

Combustible liquid. May be corrosive to metals. May be harmful if swallowed. Causes severe skin burns and eye damage. Harmful if inhaled. May cause respiratory irritation. May cause drowsiness or dizziness. May cause cancer. May cause damage to organs through prolonged or repeated exposure.

Precautionary Statements: P201-P202-P210-P234-P235-P260-P264b-P271-P281-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P370+P378q-P390-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep only in original container. Keep cool. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Use personal protective equipment as required. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Absorb spillage to prevent material damage. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,1801
Hazard Class
8
Packing Group
I
Harmonized Tariff Code
2915.90
TSCA
Yes
RTECS
LQ5860000

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