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88-10-8 - Diethylcarbamyl chloride, 98% - N,N-Diethylcarbamoyl chloride - N,N-Diethylchloroformamide - A15701 - Alfa Aesar

A15701 Diethylcarbamyl chloride, 98%

CAS Number
88-10-8
Synonyms
N,N-Diethylcarbamoyl chloride
N,N-Diethylchloroformamide

Size Price ($) Quantity Availability
25g 13.86
100g 42.39
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Diethylcarbamyl chloride, 98%

MDL
MFCD00000636
EINECS
201-798-5

Chemical Properties

Formula
C5H10ClNO
Formula Weight
135.59
Melting point
-32°
Boiling Point
186°
Flash Point
76°(168°F)
Density
1.070
Refractive Index
1.4510
Sensitivity
Moisture Sensitive
Solubility
Reacts with water.

Applications

It is used in the production of pharma ingredients. It is a reagent in the synthesis of S-Methyl-N,N-diethylthiocarbamate Sulfoxide, which is an oxygenated metabolite of Disulfiram (Antabuse) that is capable of in vitro inactivation of liver mitochondrial aldehyde dehydrogenase.

Notes

Moisture sensitive. Store away from bases, water/moisture and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Keep ignition sources away.

Literature References

A. Segal, et al. Formation of 6-dimethylcarbamyloxy-dGuo, 6-dimethylamino-dGuo and 4-dimethylamino-dThd following in vitro reaction of dimethylcarbamyl chloride with calf thymus DNA and 6-diethylcarbamyloxy-dGuo following in vitro reaction of diethylcarbamyl chloride with calf thymus DNA.Chem. Biol. Interact.,1982,40(2), 209-231.

S. Kushner, et al. Experimental chemotherapy of filariasis. v. the preparation of derivatives of piperazine.J. Org. Chem.,1948,13(1), 144-153.

GHS Hazard and Precautionary Statements

Hazard Statements: H351-H302-H332-H315-H319-H335-H227

Suspected of causing cancer. Harmful if swallowed. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Combustible liquid.

Precautionary Statements: P210-P201-P261-P280-P281-P305+P351+P338-P304+P340-P362-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
506687
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2924.19
TSCA
Yes
RTECS
FD4025000

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