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A15701 Diethylcarbamyl chloride, 98%

CAS Number
88-10-8
Synonyms
N,N-Diethylcarbamoyl chloride
N,N-Diethylchloroformamide

Stock No. Size Price ($) Quantity Availability
A15701-14 25g 15.70
A15701-22 100g 48.90
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Diethylcarbamyl chloride, 98%

MDL
MFCD00000636
EINECS
201-798-5

Chemical Properties

Formula
C5H10ClNO
Formula Weight
135.59
Melting point
-32°
Boiling Point
186°
Flash Point
76°(168°F)
Density
1.070
Refractive Index
1.4510
Storage & Sensitivity
Moisture Sensitive. Store under Nitrogen. Ambient temperatures.
Solubility
Reacts with water.

Applications

It is used in the production of pharma ingredients. It is a reagent in the synthesis of S-Methyl-N,N-diethylthiocarbamate Sulfoxide, which is an oxygenated metabolite of Disulfiram (Antabuse) that is capable of in vitro inactivation of liver mitochondrial aldehyde dehydrogenase.

Notes

Moisture sensitive. Store away from bases, water/moisture and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Keep ignition sources away.

Literature References

A. Segal, et al. Formation of 6-dimethylcarbamyloxy-dGuo, 6-dimethylamino-dGuo and 4-dimethylamino-dThd following in vitro reaction of dimethylcarbamyl chloride with calf thymus DNA and 6-diethylcarbamyloxy-dGuo following in vitro reaction of diethylcarbamyl chloride with calf thymus DNA.Chem. Biol. Interact.,1982,40(2), 209-231.

S. Kushner, et al. Experimental chemotherapy of filariasis. v. the preparation of derivatives of piperazine.J. Org. Chem.,1948,13(1), 144-153.

GHS Hazard and Precautionary Statements

Hazard Statements: H227-H302-H315-H319-H332-H335-H351

Combustible liquid. Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. Harmful if inhaled. May cause respiratory irritation. Suspected of causing cancer.

Precautionary Statements: P201-P202-P210-P235-P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P308+P313-P312-P330-P332+P313-P337+P313-P362-P370+P378q-P374-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep cool. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Rinse mouth. If skin irritation occurs: If eye irritation persists: Take off contaminated clothing and wash before reuse. In case of fire: Use CO2, dry chemical, or foam Fight fire with normal precautions from a reasonable distance. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
506687
Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2924.19
TSCA
Yes
RTECS
FD4025000

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