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476-66-4 - Ellagic acid hydrate, 97%, may cont. up to 12% water - 4,4',5,5',6,6'-Hexahydroxydiphenic acid 2,6,2',6'-dilactone hydrate - A15722 - Alfa Aesar

A15722 Ellagic acid hydrate, 97%, may cont. up to 12% water

CAS Number
476-66-4
Synonyms
4,4',5,5',6,6'-Hexahydroxydiphenic acid 2,6,2',6'-dilactone hydrate

Size Price ($) Quantity Availability
5g 40.17
25g 143.17
100g 447.02
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Ellagic acid hydrate, 97%, may cont. up to 12% water

MDL
MFCD00149494
EINECS
207-508-3

Chemical Properties

Formula
C14H6O8•xH2O
Formula Weight
302.20(anhy)
Melting point
450° dec.
Sensitivity
Air & Light Sensitive
Solubility
Slightly soluble in water. Soluble in 1M sodium hydroxide (10 mg/ml), EtOH, and pyridine.

Applications

Ellagic acid used as selective, ATP-competitive inhibitor of casein kinase 2. Exhibits antitumor activity and inhibits glutathione S-transferase. It is also used as a Topo I and II, FGR, GSK, and PKA inhibitor.Commonly occurring plant polyphenol, inhibitor of glutathione S-transferase. Used for the assay of factor XIIa in plasma.Contact activation in blood coagulation.

Notes

Air sensitive and light sensitive. Store under dry inert gas. Store in cool dry place in tightly closed container. Store in dark and away form air.

Literature References

Patrice Njomnang Soh: Benoît Witkowski; David Olagnier; Marie-Laure Nicolau; Maria-Concepcion Garcia-Alvarez; Antoine Berry; and Françoise Benoit-Vical. In Vitro and In Vivo Properties of Ellagic Acid in Malaria Treatment. Antimicrob. Agents Chemother. 2009, 31100-1106.

Sungwoo Kim; Satoru K. Nishimoto; Joel D. Bumgardnerd; Warren O. Haggardd; M. Waleed Gabere; Yunzhi Yang. A chitosan/β-glycerophosphate thermo-sensitive gel for the delivery of ellagic acid for the treatment of brain cancer. Biomaterials. 2010, 31 (14), 4157-4166.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,3547
Beilstein
47549
Harmonized Tariff Code
2932.20
TSCA
No
RTECS
DJ2620000

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