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(Formylmethyl)triphenylphosphonium Chloride is a useful Wittig reagent. Used as a reactant for Hydroazidation reactions in preparation of a-azido alcohols, Preparation of prodrug (2-hydroxyamino-vinyl)-triphenyl-phosphonium (HVTP) inhibitor of peroxidase activity and apoptosis and Intramolecular [4 + 3] cycloaddition reactions.
Klaus Banert; Christian Berndt; Samia Firdous; Manfred Hagedorn; Young-Hyuk Joo; Tobias Rüffer; Heinrich Lang. Extremely simple but long overlooked: generation of α-azido alcohols by hydroazidation of aldehydes. Angewandte Chemie. International edition in English. 2010, 49 (52), 10206-10209.
Detcho A Stoyanovsky; Irina I Vlasova; Natalia A Belikova; Alexandr Kapralov; Vladimir Tyurin; Joel S Greenberger; Valerian E Kagan. Activation of NO donors in mitochondria: peroxidase metabolism of (2-hydroxyamino-vinyl)-triphenyl-phosphonium by cytochrome c releases NO and protects cells against apoptosis. FEBS Letters. 2008, 582 (5), 725-728.
Undergoes the Wittig reaction with aldehydes to give acrylic aldehydes either in the presence of base or by prior conversion to the phosphorane. For references see (Formylmethylene)triphenylphosphorane, A11709.
Hazard Statements: H302-H318
Harmful if swallowed. Causes serious eye damage.
Precautionary Statements: P264b-P270-P280-P301+P312-P305+P351+P338-P310-P330-P501c
Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Dispose of contents/ container to an approved waste disposal plant