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A15797 1,4-Dithio-DL-threitol, 98%

CAS Number
3483-12-3
Synonyms
Cleland's Reagent DTT racemic
(±)-threo-1,4-Dimercapto-2,3-butanediol

Stock No. Size Price ($) Quantity Availability
A15797-03 1g 34.50
A15797-06 5g 98.10
A15797-14 25g 369.00
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1,4-Dithio-DL-threitol, 98%

MDL
MFCD00004877
EINECS
222-468-7

Chemical Properties

Formula
C4H10O2S2
Formula Weight
154.25
Melting point
40-43°
Boiling Point
125-130°/12mm
Flash Point
>110°(230°F)
Storage & Sensitivity
Store under Argon. Keep Cold. Air Sensitive.
Solubility
Soluble in water, ethanol, chloroform, diethyl ether, acetone, ether and ethyl acetate.

Applications

Useful for stabilizing sulfhydryl-containing enzymes1,4-Dithio-DL-threitol is used as a protective agent in preventing oxidation of thiol groups and reagent for the reduction of disulfide groups in proteins. It is employed to investigate a-ketoglutarate dehydrogenase function, flavin cofactors in proteins and protein moieties involved in peroxide reduction. It is also useful for stabilizing sulfhydryl-containing enzymes.

Notes

Air sensitive and hygroscopic. Store in a cool place. Incompatible with strong oxidizing agents, reducing agents and alkalies.

Literature References

Protective agent for preventing oxidation of thiol groups and reagent for reduction of disulfide groups in proteins: Biochemistry, 3, 480 (1964); 11, 2939 (1972); J. Biol. Chem., 243, 716 (1968); Methods Enzymol., 25, 185 (1967); 143, 246 (1987).

Yang, H. K.; Zhang, L. M. New amphiphilic glycopolypeptide conjugate capable of self-assembly in water into reduction-sensitive micelles for triggered drug release. Mater. Sci. Eng. C 2014, 41, 36-41.

Feng, L.; Xie, A.; Hu, X.; Liu, Y.; Zhang, J.; Li, S.; Dong, W. A releasable disulfide carbonate linker for polyethyleneimine (PEI)-based gene vectors. New J. Chem. 2014, 38, (11), 5207-5214.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,3376
Beilstein
1719757
Harmonized Tariff Code
2930.90
TSCA
Yes
RTECS
EK1610000

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