I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
It is used as pharmaceutical intermediate. N-alkylated 1-(2-methyoxyphenyl)piperazines markedly improved affinity and selectivity of the dopamine D3 receptor which is recognized as a potential therapeutic target for the treatment of various neurological and psychiatric disorders.
Anneke Hackling.; Robin Ghosh.; Sylvie Perachon.; André Mann.; Hans-Dieter Höltje.; Camille G. Wermuth..; Jean-Charles Schwartz .;Wolfgang Sippl.;Pierre Sokoloff.; Holger Stark. N-(ω-(4-(2-Methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as Dopamine D2 and D3 Receptor Ligands. J. Med. Chem. 2003, 46 (18),3883-3899 .
Jerzy L. Mokrosz.; Maria H. Paluchowska.; Ewa Chojnacka-Wojcik.; Malgorzata Filip.; Sijka Charakchieva-Mino.; Anna Deren-Wesolek.; Maria J. Mokrosz. Structure-Activity Relationship Studies of Central Nervous System Agents. 13.4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a New Putative 5-HT1A Receptor Antagonist, and Its Analogs. J. Med. Chem. 1994, 37 (17), 2754-2760 .
Hazard Statements: H301-H314-H318
Toxic if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P260u-P301+P310a-P303+P361+P353-P305+P351+P338-P405-P501a
Do not breathe dusts or mists. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.