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A15819 1-(2-Methoxyphenyl)piperazine, 98%

CAS Number
35386-24-4
Synonyms

Stock No. Size Price ($) Quantity Availability
A15819-06 5g 31.40
A15819-22 100g 291.00
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1-(2-Methoxyphenyl)piperazine, 98%

MDL
MFCD00005958
EINECS
252-537-7

Chemical Properties

Formula
C11H16N2O
Formula Weight
192.26
Melting point
35-39°
Boiling Point
130-133°/0.1mm
Flash Point
>110°(230°F)
Density
1.106
Storage & Sensitivity
Air Sensitive. Ambient temperatures.
Solubility
Soluble in chloroform, ethyl acetate, and methanol. Insoluble in water

Applications

It is used as pharmaceutical intermediate. N-alkylated 1-(2-methyoxyphenyl)piperazines markedly improved affinity and selectivity of the dopamine D3 receptor which is recognized as a potential therapeutic target for the treatment of various neurological and psychiatric disorders.

Notes

Air sensitive. Store at room temperature. Keep away from oxidizing agents.

Literature References

Anneke Hackling.; Robin Ghosh.; Sylvie Perachon.; André Mann.; Hans-Dieter Höltje.; Camille G. Wermuth..; Jean-Charles Schwartz .;Wolfgang Sippl.;Pierre Sokoloff.; Holger Stark. N-(ω-(4-(2-Methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as Dopamine D2 and D3 Receptor Ligands. J. Med. Chem. 2003, 46 (18),3883-3899 .

Jerzy L. Mokrosz.; Maria H. Paluchowska.; Ewa Chojnacka-Wojcik.; Malgorzata Filip.; Sijka Charakchieva-Mino.; Anna Deren-Wesolek.; Maria J. Mokrosz. Structure-Activity Relationship Studies of Central Nervous System Agents. 13.4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a New Putative 5-HT1A Receptor Antagonist, and Its Analogs. J. Med. Chem. 1994, 37 (17), 2754-2760 .

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H312-H314

Harmful if swallowed. Harmful in contact with skin. Causes severe skin burns and eye damage.

Precautionary Statements: P260-P264b-P270-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
167888
Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2933.59
TSCA
No

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