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Epichlorohydrin is used in the manufacture of polyamines and polyquaternary ammonium salts, as flocculents in water and wastewater treatment. It is used in the synthesis of surface active agents for washing products and toiletries. Polyamine-epichlorohydrin resin is used in paper industry to improve paper wet-strength. It acts as a chemical intermediate and widely used in the manufacture of epoxy resins, epichlorohydrin elastomers and polyamide-epichlorohydrin resins.
For use as an acid scavenger in bromination reactions, see: J. Am. Chem. Soc., 95, 4419 (1973).
The preparation of glycidyl ethers, often carried out in two steps, via the ring-opened chlorohydrin ether and subsequent ring-closure with base, can be achieved as a single step, under phase-transfer conditions: Synthesis, 117 (1983). For extension to diglycidyl ethers of diols, see: Synthesis, 649 (1985).
Reaction with primary amines provides a one-step route to 3-azetidinols: J. Org. Chem., 55, 2920 (1990):
Zhang, Y.; Tan, Z.; Liu, B.; Mao, D.; Xiong, C. Coconut shell activated carbon tethered ionic liquids for continuous cycloaddition of CO2 to epichlorohydrin in packed bed reactor. Catal. Commun. 2015, 68, 73-76.
Xiao, S.; Zhang, C.; Chen, R.; Chen, F. Selective oxidation of benzyl alcohol to benzaldehyde with H2O2 in water on epichlorohydrin-modified Fe3O4 microspheres. New. J. Chem. 2015, 39 (6), 4924-4932.
Hazard Statements: H226-H301-H311-H331-H314-H317-H350
Flammable liquid and vapour. Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled. Causes severe skin burns and eye damage. May cause an allergic skin reaction. May cause cancer.
Precautionary Statements: P210-P301+P310a-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.