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A15830 3-Amino-2-chloropyridine, 98+%

CAS Number
6298-19-7
Synonyms
2-Chloro-3-pyridinamine
2-Chloro-3-pyridan-3-ylamine

Stock No. Size Price ($) Quantity Availability
A15830-09 10g 28.80
A15830-18 50g 97.40
A15830-30 250g 371.00
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3-Amino-2-chloropyridine, 98+%

MDL
MFCD00006238
EINECS
228-572-9

Chemical Properties

Formula
C5H5ClN2
Formula Weight
128.56
Melting point
76-80°
Boiling Point
130-134°/22mm
Flash Point
185°(365°F)
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in methanol and water. (30 g/L).

Applications

It is an intermediate of medicine and agricultural chemicals. It is involved in the Suzuki-Miyaura cross-coupling reactions of heteroaryl compounds.

Notes

Store at room temperature. Keep away from oxidizing agents.

Literature References

J. M. Bakke.; J. Riha. Preparation of 4-substituted 3-amino-2-chloropyridines, synthesis of a nevirapine analogue.Journal of Heterocyclic Chemistry. 2001, 38 (1),99-104 .

Takahiro Itoh.; Toshiaki Mase. Direct synthesis of hetero-biaryl compounds containing an unprotected NH2 group via Suzuki-Miyaura reaction. Tetrahedron Lett. 2005, 46 (20),3573-3577 .

Reaction with aroyl halides, followed by cyclization with PPSE (see Hexamethyl­disiloxane, A11848), gives oxazolo[5,4-b]pyridines in high yield: Synthesis, 64 (1990):

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
109814
Harmonized Tariff Code
2933.39
TSCA
No

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