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It is an intermediate of medicine and agricultural chemicals. It is involved in the Suzuki-Miyaura cross-coupling reactions of heteroaryl compounds.
J. M. Bakke.; J. Riha. Preparation of 4-substituted 3-amino-2-chloropyridines, synthesis of a nevirapine analogue.Journal of Heterocyclic Chemistry. 2001, 38 (1),99-104 .
Takahiro Itoh.; Toshiaki Mase. Direct synthesis of hetero-biaryl compounds containing an unprotected NH2 group via Suzuki-Miyaura reaction. Tetrahedron Lett. 2005, 46 (20),3573-3577 .
Reaction with aroyl halides, followed by cyclization with PPSE (see Hexamethyldisiloxane, A11848), gives oxazolo[5,4-b]pyridines in high yield: Synthesis, 64 (1990):
Hazard Statements: H312-H315-H319-H335
Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P280h-P305+P351+P338
Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.