I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
4-Nitrophthalic Anhydride is an intermediate for the synthesis of the benzimidazole PARP inhibitor I, ABT-472. It reacts with aminoquinazolinones to yield phthalimidoquinazolinones.
Ben H. Nicolet.; Jacob Sacks.3-Nitrophthalic Anhydride As A Reagent For Alcohols.J. Am. Chem. Soc. 1925, 47 (9),2348-2350 .
E. Wertheim. Derivatives For The Identification Of Mercaptans. J. Am. Chem. Soc. 1929, 51 (12),3661-3664 .
Has been used as an N-blocking group for amino acids in solid-phase peptide synthesis, providing an acidic 'handle' allowing separation by ion-exchange chromatography: Angew. Chem. Int. Ed., 8, 764 (1969). See Appendix 6.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.