Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

641-70-3 - 3-Nitrophthalic anhydride, 97% - A15857 - Alfa Aesar

A15857 3-Nitrophthalic anhydride, 97%

CAS Number
641-70-3
Synonyms

Size Price ($) Quantity Availability
25g 118.56
100g 352.98
500g 1165.60
Add to Cart Add to Quote Request View Item

3-Nitrophthalic anhydride, 97%

MDL
MFCD00005921
EINECS
211-373-6

Chemical Properties

Formula
C8H3NO5
Formula Weight
193.11
Melting point
161-166°
Sensitivity
Moisture Sensitive
Solubility
May decompose in water.

Applications

4-Nitrophthalic Anhydride is an intermediate for the synthesis of the benzimidazole PARP inhibitor I, ABT-472. It reacts with aminoquinazolinones to yield phthalimidoquinazolinones.

Notes

Air sensitive. Store at room temperature. Keep away from oxidizing agents.

Literature References

Ben H. Nicolet.; Jacob Sacks.3-Nitrophthalic Anhydride As A Reagent For Alcohols.J. Am. Chem. Soc. 1925, 47 (9),2348-2350 .

E. Wertheim. Derivatives For The Identification Of Mercaptans. J. Am. Chem. Soc. 1929, 51 (12),3661-3664 .

Has been used as an N-blocking group for amino acids in solid-phase peptide synthesis, providing an acidic 'handle' allowing separation by ion-exchange chromatography: Angew. Chem. Int. Ed., 8, 764 (1969). See Appendix 6.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
179963
Harmonized Tariff Code
2917.39
TSCA
Yes

Recommended

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware