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A15857 3-Nitrophthalic anhydride, 97%

CAS Number
641-70-3
Synonyms

Stock No. Size Price ($) Quantity Availability
A15857-14 25g 126.00
A15857-22 100g 403.00
A15857-36 500g 1412.00
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3-Nitrophthalic anhydride, 97%

MDL
MFCD00005921
EINECS
211-373-6

Chemical Properties

Formula
C8H3NO5
Formula Weight
193.11
Melting point
161-166°
Storage & Sensitivity
Moisture Sensitive. Ambient temperatures.
Solubility
May decompose in water.

Applications

4-Nitrophthalic Anhydride is an intermediate for the synthesis of the benzimidazole PARP inhibitor I, ABT-472. It reacts with aminoquinazolinones to yield phthalimidoquinazolinones.

Notes

Air sensitive. Store at room temperature. Keep away from oxidizing agents.

Literature References

Ben H. Nicolet.; Jacob Sacks.3-Nitrophthalic Anhydride As A Reagent For Alcohols.J. Am. Chem. Soc. 1925, 47 (9),2348-2350 .

E. Wertheim. Derivatives For The Identification Of Mercaptans. J. Am. Chem. Soc. 1929, 51 (12),3661-3664 .

Has been used as an N-blocking group for amino acids in solid-phase peptide synthesis, providing an acidic 'handle' allowing separation by ion-exchange chromatography: Angew. Chem. Int. Ed., 8, 764 (1969). See Appendix 6.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
179963
Harmonized Tariff Code
2917.39
TSCA
Yes

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