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4-tert-butylphenol on condensation with formaldehyde gives calixarene which is used in enzyme mimetics.
C. David Gutsche.; Balram Dhawan.; Kwang Hyun No.; Ramamurthi Muthukrishnan. Calixarenes. 4. The synthesis, characterization, and properties of the calixarenes from p-tert-butylphenol. J. Am. Chem. Soc. 1981, 103 (13),3782-3792 .
The acid-catalyzed removal of t-butyl groups from phenols (reverse Friedel-Crafts reaction), can be brought about without the need for t-butyl acceptors by using aluminum chloride as catalyst in dichloromethane at ambient temperature: Synth. Commun., 18, 1783 (1988).
Hazard Statements: H315-H318-H335-H361f
Causes skin irritation. Causes serious eye damage. May cause respiratory irritation. Suspected of damaging fertility.
Precautionary Statements: P201-P202-P261-P264b-P271-P281-P302+P352-P304+P340-P305+P351+P338-P308+P313-P310-P332+P313-P362-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Use personal protective equipment as required. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Immediately call a POISON CENTER or doctor/physician. If skin irritation occurs: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant