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4-tert-butylphenol on condensation with formaldehyde gives calixarene which is used in enzyme mimetics.
C. David Gutsche.; Balram Dhawan.; Kwang Hyun No.; Ramamurthi Muthukrishnan. Calixarenes. 4. The synthesis, characterization, and properties of the calixarenes from p-tert-butylphenol. J. Am. Chem. Soc. 1981, 103 (13),3782-3792 .
The acid-catalyzed removal of t-butyl groups from phenols (reverse Friedel-Crafts reaction), can be brought about without the need for t-butyl acceptors by using aluminum chloride as catalyst in dichloromethane at ambient temperature: Synth. Commun., 18, 1783 (1988).
Hazard Statements: H303-H313-H315-H318-H317-H335
May be harmful if swallowed. May be harmful in contact with skin. Causes skin irritation. Causes serious eye damage. May cause an allergic skin reaction. May cause respiratory irritation.
Precautionary Statements: P262-P273-P280h-P305+P351+P338-P337+P313
Do not get in eyes, on skin, or on clothing. Avoid release to the environment. Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention.