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Sodium diethyldithiocarbamate trihydrate is a spin trapping reagent used in conjunction with ferrous ion to detect nitric oxide in brain, kidney, liver and other tissues. It is used as sensitive reagent for the determination of copper, rubber vulcanization accelerator and finds application in the determination of other metals such as zinc, cobalt, platinum and palladium. Furthermore, it is an inhibitor of superoxide dismutase, ascorbate oxidase and other enzymes as well as inhibits the induction of macrophage nitric oxide synthase.
Reagent for extraction of heavy metals: Anal. Chem., 54, 2536 (1982).
Pang, H.; Chen, D.; Cui, Q. C.; Dou, Q. P. Sodium diethyldithiocarbamate, an AIDS progression inhibitor and a copper-binding compound, has proteasome-inhibitory and apoptosis-inducing activities in cancer cells. Int. J. Mol. Med. 2007, 19 (5), 809-816.
Radovan, C.; Manea, F. Determination of Sodium Diethyldithiocarbamate in Water by Anodic Voltammetry Using a Boron-Doped Diamond Electrode. Electroanalysis 2007, 19 (1), 91-95.
Hazard Statements: H302
Harmful if swallowed.
Precautionary Statements: P264-P270-P301+P312a-P330-P501a
Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.