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4431-00-9 - Aurintricarboxylic acid - A15905 - Alfa Aesar

A15905 Aurintricarboxylic acid

CAS Number
4431-00-9
Synonyms

Size Price ($) Quantity Availability
5g 31.93
25g 98.16
100g 314.15
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Aurintricarboxylic acid

MDL
MFCD00011663
EINECS
224-628-1

Chemical Properties

Formula
C22H14O9
Formula Weight
422.35
Melting point
>300°
Solubility
Insoluble in water.

Applications

Aurintricarboxylic acid is employed as a powerful inhibitor of cellular processes, including apoptosis, that are dependent on the formation of protein-nucleic acid complexes. It binds to a FGF and reduces its angiogenic activity. Aurintricarboxylic Acid has been shown to inhibit apoptotic cell death in various cell types induced by a variety of factors. It Inhibits protein-nucleic acid interactions. It stimulates the tyrosine phosphorylation of MAP kinases.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with strong bases and strong oxidizing agents.

Literature References

Richard B. Hallick.; Barry K. Chelm.; Patrick W. Gray.; Emil M. Orozco Jr. Use of aurintricarboxylic acid as an inhibitor of nucleases during nucleic acid isolation. Nucl. Acids Res. 1979, 4 (9),3055-3064.

Jill M. Roberts-Lewis.; Val R. Marcy.; Yonghua Zhao.; Jeffry L. Vaught.; Robert Siman.; Michael E. Lewis. Aurintricarboxylic Acid Protects Hippocampal Neurons from NMDA-and Ischemia-Induced Toxicity In Vivo. Journal of Neurochemistry. 1993, 61 (1), 378-381.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
2228904
Harmonized Tariff Code
2918.99
TSCA
Yes
RTECS
GU4790000

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