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98-92-0 - Nicotinamide, 99% - Niacinamide - Pyridine-3-carboxamide - A15970 - Alfa Aesar

A15970 Nicotinamide, 99%

CAS Number
98-92-0
Synonyms
Niacinamide
Pyridine-3-carboxamide

Size Price ($) Quantity Availability
100g 15.30
250g 26.03
1000g 73.53
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Nicotinamide, 99%

MDL
MFCD00006395
EINECS
202-713-4

Chemical Properties

Formula
C6H6N2O
Formula Weight
122.13
Melting point
128-132°
Flash Point
182°(360°F)
Density
1.40
Solubility
Soluble in water, ethanol , glycerol, DMSO , methanol, butanol and chloroform. Slightly soluble in ether.

Applications

Nicotinamide is a building block (active component) of coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phopshate (NADP). It may be used as a substrate of nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12), the rate-limiting enzyme for NAD(+) biosynthesis and an important signaling molecule. It is an amide derivative of vitamin B3 and a PARP inhibitor.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Literature References

Kevin J.Bitterman; Rozalyn M.Anderson; Haim Y.Cohen; Magda Latorre-Esteves; David A.Sinclair. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of Yeast Sir2 and Human SIRT1. The Journal of Biological Chemistry. 2002, 277, (47),45099-45107

 

Rozalyn M.Anderson; Kevin J.Bitterman; Jason G.Wood; Oliver Medvedik; David A.Sinclair. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Letters to Nature. 2003, 423, 181-185

GHS Hazard and Precautionary Statements

Hazard Statements: H319

Causes serious eye irritation.

Precautionary Statements: P280-P264-P305+P351+P338-P337+P313

Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention.

Other References

Merck
14,6523
Beilstein
383619
Harmonized Tariff Code
2936.29
TSCA
Yes
RTECS
QS3675000

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