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A16006 cis-Aconitic anhydride, 98%

CAS Number
6318-55-4
Synonyms
2,5-Dihydro-2,5-dioxofuran-3-acetic acid
Propene-1,2,3-tricarboxylic anhydride

Stock No. Size Price ($) Quantity Availability
A16006-03 1g 38.90
A16006-06 5g 143.00
A16006-14 25g 562.00
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cis-Aconitic anhydride, 98%

MDL
MFCD00005524
EINECS
228-663-3

Chemical Properties

Formula
C6H4O5
Formula Weight
156.10
Melting point
74-78°
Storage & Sensitivity
Keep Cold. Moisture Sensitive.

Applications

cis-Aconitic anhydride is used in the preparation of poly(amino acid)-containing copolymers with gradient pH-sensitive side groups initiated by the amino groups in methoxy poly(ethylene glycol)-block-poly(L-lysine). It is also involved in the preparation of pH-sensitive anti-tumor prodrug nanoparticles by conjugation with D-alfa-tocopheryl polyethylene glycol 1000 succinate (TPGS).

Notes

Moisture sensitive. Incompatible with strong acids, strong oxidizing agents and strong bases. Store in a cool place.

Literature References

Sun, D.; Ding, J.; Xiao, C.; Chen, J.; Zhuang, X.; Chen, X. pH-Responsive Reversible PEGylation Improves Performance of Antineoplastic Agent. Adv. Healthcare Mater. 2015, 4 (6), 844-855.

Chen, J.; Ding, J.; Zhang, Y.; Xiao, C.; Zhuang, X.; Chen, X. Polyion complex micelles with gradient pH-sensitivity for adjustable intracellular drug delivery. Polym. Chem. 2015, 6 (3), 397-405.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H335

Causes severe skin burns and eye damage. May cause respiratory irritation.

Precautionary Statements: P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
127575
Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2917.19
TSCA
Yes

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