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951-78-0 - 2'-Deoxyuridine, 99% - 1-(2-Deoxy-beta-D-ribofuranosyl)uracil - Uracil deoxyriboside - A16026 - Alfa Aesar

A16026 2'-Deoxyuridine, 99%

CAS Number
951-78-0
Synonyms
1-(2-Deoxy-beta-D-ribofuranosyl)uracil
Uracil deoxyriboside

Size Price ($) Quantity Availability
1g 57.99
5g 202.50
25g 852.58
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2'-Deoxyuridine, 99%

MDL
MFCD00006527
EINECS
213-455-7

Chemical Properties

Formula
C9H12N2O5
Formula Weight
228.21
Melting point
164-167°
Sensitivity
Air Sensitive
Solubility
Soluble in water.

Applications

2'-Deoxyuridine is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms. Derivatized 2?-Deoxyuridines used as labeling substrates include chloro-2?-deoxyuridine (CldU), bromodeoxyuridine (BrdU) and/or iododeoxyuridine (IdU). Other useful analogues of 2?-deoxyuridine include 5-ethynyl-2?-deoxyuridine (DdU) and 5-hydroxymethyl-2?-deoxyuridine (HmdU). Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies. Deoxyuridine (dU) is used to indirectly determine if there are sufficient levels of folate and cobalamin in cell or tissue samples.

Notes

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents. It is sensitive to air.

Literature References

Brenton L Cavanagh, Tom Walker, Anwar Norazit, Adrian C B Meedeniya. Thymidine analogues for tracking DNA synthesis. Molecules. 2011, 16 (9, 7980-7993.

De Clercq, E., Descamps, J., De Somer, P., Barr, P. J., Jones, A. S., & Walker, R. T. (E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent. Proceedings of the National Academy of Sciences. 1979, 76 (6), 2947-2951.

Other References

Merck
14,2910
Beilstein
24433
Harmonized Tariff Code
2934.99
TSCA
Yes
RTECS
YU7490000

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