Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

5457-28-3 - Indole-3-carbonitrile, 98% - 3-Cyanoindole - A16041 - Alfa Aesar

A16041 Indole-3-carbonitrile, 98%

CAS Number
5457-28-3
Synonyms
3-Cyanoindole

Size Price ($) Quantity Availability
1g 32.38
5g 130.81
25g 409.14
Add to Cart Add to Quote Request View Item

Indole-3-carbonitrile, 98%

MDL
MFCD00022717
EINECS
000-000-0

Chemical Properties

Formula
C9H6N2
Formula Weight
142.16
Melting point
177-182°
Sensitivity
Light Sensitive
Solubility
Insoluble in water.

Applications

Indole-3-carbonitrile is used as a synthesis reagent for preparation of 4-substituted β-lactams, biologically active indoles, inhibitors of glycogen synthase kinase 3β (GSK-3), indole fragments as inosine monophosphate dehydrogenase (IMPDH) inhibitors and HIV-1 integrase inhibitors. It is also used as a reactant for intramolecular oxidative C-H coupling reactions with applications in medium-ring synthesis techniques and for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators.

Notes

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents. It is sensitive to light.

Literature References

Didier G Pintori.; Michael F Greaney. Intramolecular oxidative C-H coupling for medium-ring synthesis. Journal of the American Chemical Society. 2011, 133 (5), 1209-1211.

F Y Miyake.; K Yakushijin, D A Horne. A concise synthesis of topsentin A and nortopsentins B and D. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2000, 2 (14), 2121-2123.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
120888
Harmonized Tariff Code
2933.99
TSCA
No

Recommended

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware