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Heparin sodium salt is used as a blood anti-coagulant. It is also used as an effective inhibitor of mesenchymal cell proliferation. Further, it binds to antithrombin III, which inhibits coagulation proteases. It is used as a major component of serum free media for preventing cell aggregation. It is also used as an anti-cancer agent in in vitro cancer research.
dAngelo, I.; Oliviero, O.; Ungaro, F.; Quaglia, F.; Netti, P. A. Engineering strategies to control vascular endothelial growth factor stability and levels in a collagen matrix for angiogenesis: The role of heparin sodium salt and the PLGA-based microsphere approach. Acta Biomater. 2013, 9 (7), 7389-7398..
Bhalerao, U. M.; Valiveti, A. K.; Acharya, J.; Halve, A. K.; Kaushik, M. P. Controlled release studies of antimalarial 1, 3, 5-trisubstituted-2-pyrazolines from biocompatible chitosan-heparin Layer-by-Layer (LbL) self assembled thin films. Colloids Surf., B 2015, 125, 151-159.