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Tetramethylurea is used as a solvent in dyestuff industries, in condensation reaction and intermediates in surfactant. It is utilized for base catalyzed isomerization and alkylation hydrocyanation due to its low permittivity. It reacts with oxalyl chloride to prepare tetramethyl chloroformamidinium chloride, which is used for the conversion of carboxylic acids and dialkyl phosphates to anhydrides and pyrophosphates respectively.
High-boiling dipolar aprotic solvent. The polar nature, wide liquid range and high solvent power of tetraalkylureas make them suitable solvents for a wide range of reactions; review: Angew. Chem. Int. Ed., 18, 503 (1979).
Reacts with oxalyl chloride to give tetramethyl chloroformamidinium chloride, a useful reagent for the conversion of carboxylic acids and dialkyl phosphates to anhydrides and pyrophosphates respectively: Bull. Chem. Soc. Jpn., 56, 3529 (1983).
Indra, S.; Biswas, R. Hydrogen-bond dynamics of water in presence of an amphiphile, tetramethylurea: signature of confinement-induced effects. Mol. Simul. 2015, 41 (5-6), 471-482.
Krakowiak, J.; Wawer, J. Effect of temperature and ionic strength on volumetric and acoustic properties of solutions of urea alkyl derivatives in aqueous NaCl. J. Chem. Thermodyn. 2015, 90, 232-241.
Hazard Statements: H227-H302-H360D
Combustible liquid. Harmful if swallowed. May damage the unborn child.
Precautionary Statements: P201-P202-P210-P264b-P270-P281-P301+P312-P308+P313-P330-P370+P378q-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use personal protective equipment as required. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF exposed or concerned: Get medical advice/attention. Rinse mouth. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant