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Trimethylacetylacetonitrile is a useful intermediate. 4,4-Dimethyl-3-oxopentanenitrile has been used in the preparation of 4,4-dimethyl-3-oxo-2-benzylpentanenitrile, 4,4-dimethyl-3-oxo-2-(4-hydroxybenzyl)pentanenitrile, 4,4-dimethyl-3-oxo-2-(4-methoxybenzyl)pentanenitrile, 4,4-dimethyl-3-oxo-2-(4-fluorobenzyl)pentanenitrile, 4,4-dimethyl-3-oxo-2-(3,4-methylenedioxybenzyl)pentanenitrile, 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-phenylurea.
Phillip J Black et. al. Borrowing hydrogen: iridium-catalysed reactions for the formation of C-C bonds from alcohols. . Organic & Biomolecular Chemistry, 2006, 4 1), 116-125 .
John Regan et. al. Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate.. Journal name. 2002, 45(14), 2994-3008.
Hazard Statements: H301
Toxic if swallowed.
Precautionary Statements: P264-P270-P301+P310a-P321-P405-P501a
Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Specific treatment (see label). Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.