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Used in the preparation of regulation of phenolic acid synthesis in Bacillus subtilis. Also used in the bacterial decarboxylation of o-phthalic acids.
Nandi CK,; Hazra MK,; Chakraborty T. Conformational effects on vibronic spectra and excited state dynamics of 3-fluorobenzoic acid dimer. The Journal of Chemical Physics . 2004, 121 (11), 5261-5271.
Lynne H. Thomas,; Gavin A. Craig,; Matthias J. Gutmann,; Andrew Parkin,; Kenneth Shanklande,; Chick C. Wilson. Conformational polymorphism of the molecular complex of 3-fluorobenzoic acid with 4-acetylpyridine. CrystEngComm. 2011, 13 3349-3354.
Lithiation of the unprotected acid, with 2.2 moles of s-BuLi in the presence of TMEDA, occurs at the 2-position; subsequent reaction with hexachloroethane or dibromotetrachloroethane provides access to 2-chloro-3-fluoro- and 2-bromo-3-fluorobenzoic acid respectively: Tetrahedron Lett., 36, 881 (1995); Bull. Soc. Chim. Fr., 133, 133 (1996).
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.