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75462-59-8 - 3,5-Bis(trifluoromethyl)benzyl chloride, 97% - A16553 - Alfa Aesar

A16553 3,5-Bis(trifluoromethyl)benzyl chloride, 97%

CAS Number
75462-59-8
Synonyms

Size Price ($) Quantity Availability
1g 31.93
5g 115.86
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3,5-Bis(trifluoromethyl)benzyl chloride, 97%

MDL
MFCD00009906
EINECS
278-216-1

Chemical Properties

Formula
C9H5ClF6
Formula Weight
262.58
Melting point
29-33°
Boiling Point
46°/3mm
Flash Point
71°(161°F)
Solubility
Slightly soluble in water.

Applications

3,5-Bis(trifluoromethyl)benzyl chloride has been used in the preparation of 1-(azidomethyl)-3,5-bis-(trifluoromethyl)benzene. 1-(azidomethyl)-3,5-bis-(trifluoromethyl)benzene, in 94% yield by an efficient nucleophilic substitution reaction between 3,5-bis-(trifluoromethyl)benzyl chloride, 4, and sodium azide.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

Kopach ME, et al. Improved synthesis of 1-(azidomethyl)-3, 5-bis-(trifluoromethyl) benzene: development of batch and microflow azide processes. Org. Process Res. Dev.. 2009, 13 (2), 152-60.

Arihiro Iwata,; Joji Ohshita,; Heqing Tang,; Atsutaka Kunai. Ring-Opening Iodo- and Bromosilation of Lactones for the Formation of Silyl Haloalkanoates. J. Org. Chem. 2009, 67 (11), 3927-3929.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
656502
Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2903.99
TSCA
No

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