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106-96-7 - Propargyl bromide, 80% in toluene, stab. with MgO - 3-Bromo-1-propyne - A16580 - Alfa Aesar

A16580 Propargyl bromide, 80% in toluene, stab. with MgO

CAS Number
106-96-7
Synonyms
3-Bromo-1-propyne

Size Price ($) Quantity Availability
50ml 50.88
250ml 176.13
1000ml 623.15
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Propargyl bromide, 80% in toluene, stab. with MgO

MDL
MFCD00000241
EINECS
203-447-1

Chemical Properties

Formula
HC≡CCH2Br
Formula Weight
118.97
Melting point
-61°
Boiling Point
88-90°
Flash Point
3°(37°F)
Density
1.335
Refractive Index
1.4940
Sensitivity
Light Sensitive
Solubility
Miscible with ethanol, ether, benzene, carbon tetrachloride and chloroform. Immiscible with water.

Applications

Propargyl bromide, 80% in toluene is used to prepare betulonic acid-peptide conjugates with anti-inflammatory activity and propargylic amines employed in enyne metathesis. It finds application in the propargylation of spiro ketones, allylic alcohols and enone complexes. In Barbier-type reaction, it reacts with aldehydes to give alkyne alcohols. It is actively involved in the synthesis of polyethylene glycol (PEG) and peptide-grafted polyesters.

Notes

Light sensitive. Store in a cool place. Incompatible withbases, strong oxidizing agents, copper, peroxides, silver, silver oxides, mercury and mercury oxides.

Literature References

Li, Y.; Cheng, B. One-pot synthesis of precise polyisoxazoles by click polymerization: Copper (I)-catalyzed 1, 3-dipolar cycloaddition of nitrile oxides with alkynes. J. Polym. Sci. A Polym. Chem. 2013, 51 (7), 1645-1650.

Un, I.; Ibisoglu, H.; Un, S. S.; Cosut, B.; Kılıc, A. Syntheses, characterizations, thermal and photophysical properties of cyclophosphazenes containing adamantane units. Inorg. Chim. Acta 2013, 399, 219-226.

GHS Hazard and Precautionary Statements

Hazard Statements: H225-H301-H335-H336-H304-H361-H373-H314

Highly flammable liquid and vapour. Toxic if swallowed. May cause respiratory irritation. May cause drowsiness or dizziness. May be fatal if swallowed and enters airways. Suspected of damaging fertility or the unborn child. May cause damage to organs through prolonged or repeated exposure. Causes severe skin burns and eye damage.

Precautionary Statements: P210-P260-P201-P261-P301+P310-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
605309
Hazard Class
3
Packing Group
II
Harmonized Tariff Code
2903.39
TSCA
Yes
RTECS
UK4375000

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