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A16580 Propargyl bromide, 80% in toluene, stab. with MgO

CAS Number
106-96-7
Synonyms
3-Bromo-1-propyne

Stock No. Size Price ($) Quantity Availability
A16580-AD 50ml 78.70
A16580-AK 250ml 354.00
A16580-AU 1000ml 1002.00
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Propargyl bromide, 80% in toluene, stab. with MgO

MDL
MFCD00000241
EINECS
203-447-1

Chemical Properties

Formula
HC≡CCH2Br
Formula Weight
118.97
Melting point
-61°
Boiling Point
88-90°
Flash Point
3°(37°F)
Density
1.335
Refractive Index
1.4940
Storage & Sensitivity
Keep Cold. Light Sensitive.
Solubility
Miscible with ethanol, ether, benzene, carbon tetrachloride and chloroform. Immiscible with water.

Applications

Propargyl bromide, 80% in toluene is used to prepare betulonic acid-peptide conjugates with anti-inflammatory activity and propargylic amines employed in enyne metathesis. It finds application in the propargylation of spiro ketones, allylic alcohols and enone complexes. In Barbier-type reaction, it reacts with aldehydes to give alkyne alcohols. It is actively involved in the synthesis of polyethylene glycol (PEG) and peptide-grafted polyesters.

Notes

Light sensitive. Store in a cool place. Incompatible withbases, strong oxidizing agents, copper, peroxides, silver, silver oxides, mercury and mercury oxides.

Literature References

Li, Y.; Cheng, B. One-pot synthesis of precise polyisoxazoles by click polymerization: Copper (I)-catalyzed 1, 3-dipolar cycloaddition of nitrile oxides with alkynes. J. Polym. Sci. A Polym. Chem. 2013, 51 (7), 1645-1650.

Un, I.; Ibisoglu, H.; Un, S. S.; Cosut, B.; Kılıc, A. Syntheses, characterizations, thermal and photophysical properties of cyclophosphazenes containing adamantane units. Inorg. Chim. Acta 2013, 399, 219-226.

GHS Hazard and Precautionary Statements

Hazard Statements: H225-H301-H304-H314-H335-H336-H361-H373

Highly flammable liquid and vapour. Toxic if swallowed. May be fatal if swallowed and enters airways. Causes severe skin burns and eye damage. May cause respiratory irritation. May cause drowsiness or dizziness. Suspected of damaging fertility or the unborn child. May cause damage to organs through prolonged or repeated exposure.

Precautionary Statements: P201-P202-P210-P233-P235-P240-P241-P242-P243-P260-P264b-P270-P271-P281-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P370+P378q-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Use personal protective equipment as required. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
605309
Hazard Class
3
Packing Group
II
Harmonized Tariff Code
2903.39
TSCA
Yes
RTECS
UK4375000

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