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A16591 2-Fluoro-4-methylaniline, 99%

CAS Number
452-80-2
Synonyms
4-Amino-3-fluorotoluene
2-Fluoro-p-toluidine

Stock No. Size Price ($) Quantity Availability
A16591-06 5g 94.60
A16591-14 25g 343.00
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2-Fluoro-4-methylaniline, 99%

MDL
MFCD00040975

Chemical Properties

Formula
C7H8FN
Formula Weight
125.15
Boiling Point
70-71°/7mm
Flash Point
79°(174°F)
Density
1.108
Refractive Index
1.5330
Storage & Sensitivity
Ambient temperatures.
Solubility
Not miscible in water.

Applications

2-Fluoro-4-methylaniline is used in the preparation of 6-chloro-5-fluoroindole via Leimgruber-Batcho reaction. It is also used in the preparation of an (S)-amino alcohol, 2-amino-3-(2-fluoro-4-methylphenyl)-propan-1-ol.

Notes

Store in a cool, dry, conditions in well sealed container. Store away from oxidizing agents.

Literature References

Sharon T Marino; Danuta Stachurska-Buczek; Daniel A Huggins; Beata M Krywult; Craig S Sheehan; Thao Nguyen; Neil Choi, Jack G Parsons; Peter G Griffiths; Ian W James; Andrew M Bray; Jonathan M White; Rustum S Boyce. Synthesis of chiral building blocks for use in drug discovery. Molecules. 2004, 9 (6), 405-426.

S Boeren; B Tyrakowska; J Vervoort; E De Hoffman; K Teunis; A van Veldhuizen; I M Rietjens. Rat liver microsomal metabolism of 2-halogenated 4-methylanilines. Xenobiotica. 1992, 22 (12), 1403-1423.

GHS Hazard and Precautionary Statements

Hazard Statements: H227-H301-H311-H315-H319-H331-H335

Combustible liquid. Toxic if swallowed. Toxic in contact with skin. Causes skin irritation. Causes serious eye irritation. Toxic if inhaled. May cause respiratory irritation.

Precautionary Statements: P210-P235-P261-P264b-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P311-P312-P330-P332+P313-P337+P313-P361-P363-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep cool. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician. Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Remove/Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
2637578
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2921.43
TSCA
No
RTECS
XU6650000

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