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452-80-2 - 2-Fluoro-4-methylaniline, 99% - 4-Amino-3-fluorotoluene - 2-Fluoro-p-toluidine - A16591 - Alfa Aesar

A16591 2-Fluoro-4-methylaniline, 99%

CAS Number
452-80-2
Synonyms
4-Amino-3-fluorotoluene
2-Fluoro-p-toluidine

Size Price ($) Quantity Availability
5g 91.80
25g 362.12
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2-Fluoro-4-methylaniline, 99%

MDL
MFCD00040975

Chemical Properties

Formula
C7H8FN
Formula Weight
125.15
Boiling Point
70-71°/7mm
Flash Point
79°(174°F)
Density
1.108
Refractive Index
1.5330
Solubility
Not miscible in water.

Applications

2-Fluoro-4-methylaniline is used in the preparation of 6-chloro-5-fluoroindole via Leimgruber-Batcho reaction. It is also used in the preparation of an (S)-amino alcohol, 2-amino-3-(2-fluoro-4-methylphenyl)-propan-1-ol.

Notes

Store in a cool, dry, conditions in well sealed container. Store away from oxidizing agents.

Literature References

Sharon T Marino; Danuta Stachurska-Buczek; Daniel A Huggins; Beata M Krywult; Craig S Sheehan; Thao Nguyen; Neil Choi, Jack G Parsons; Peter G Griffiths; Ian W James; Andrew M Bray; Jonathan M White; Rustum S Boyce. Synthesis of chiral building blocks for use in drug discovery. Molecules. 2004, 9 (6), 405-426.

S Boeren; B Tyrakowska; J Vervoort; E De Hoffman; K Teunis; A van Veldhuizen; I M Rietjens. Rat liver microsomal metabolism of 2-halogenated 4-methylanilines. Xenobiotica. 1992, 22 (12), 1403-1423.

GHS Hazard and Precautionary Statements

Hazard Statements: H311-H302-H332-H315-H319-H373-H227

Toxic in contact with skin. Harmful if swallowed. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause damage to organs through prolonged or repeated exposure. Combustible liquid.

Precautionary Statements: P210-P260-P261-P280-P305+P351+P338-P361-P304+P340-P362-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Remove/Take off immediately all contaminated clothing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
2637578
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2921.43
TSCA
No
RTECS
XU6650000

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