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1135-40-6 - CAPS, 99% - 3-Cyclohexylamino-1-propanesulfonic acid - A17037 - Alfa Aesar

A17037 CAPS, 99%

CAS Number
1135-40-6
Synonyms
3-Cyclohexylamino-1-propanesulfonic acid

Size Price ($) Quantity Availability
25g 21.51
100g 55.72
500g 166.92
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CAPS, 99%

MDL
MFCD00003837
EINECS
214-492-1

Chemical Properties

Formula
C9H19NO3S
Formula Weight
221.32
Melting point
324°
Solubility
Highly water soluble (100 g/L) at 20°C, and methanol (1%).

Applications

Used to formulate CAPS buffer, a zwitterionic buffer useful in the range of pH 7.9-11.1. CAPS buffer is widely used in Western and immunoblotting experiments as well as protein sequencing and identification. Used in the electro transfer of proteins to PVDF (sc-3723) or nitrocellulose membranes (sc-3718, sc-3724). The high pH of this buffer makes it useful for the transfer of proteins with a pI > 8.5. and minimal reactivity with enzymes or proteins, minimal salt effects.

Notes

Store away from oxidizing agents. Keep the container tightly sealed and store in cool, dry condition in well ventilated place.

Literature References

Jelena Zaitseva.; I Barry Holland.; Lutz Schmitt. The role of CAPS buffer in expanding the crystallization space of the nucleotide-binding domain of the ABC transporter haemolysin B from Escherichia coli.Acta Crystallogr D Biol Crystallogr.2004,60(6), 1076-1084.

Daniele de Sanctis.; Sylvia Dewilde.; Clemens Vonrhein.; Alessandra Pesce.; Luc Moens.; Paolo Ascenzi.; Thomas Hankeln.; Thorsten Burmester.; Marco Ponassi.; Marco Nardini.; Martino Bolognesi. Bishistidyl heme hexacoordination, a key structural property in Drosophila melanogaster hemoglobin.J Biol Chem.2005,280,(29), 27222-27229.

Buffer, pKa = 10.40 at 20o: Biochemistry, 5, 467 (1966).

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,1767
Beilstein
2835588
Harmonized Tariff Code
2921.30
TSCA
Yes
RTECS
TZ6395000

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