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A17037 CAPS, 99%

CAS Number
1135-40-6
Synonyms
3-Cyclohexylamino-1-propanesulfonic acid

Stock No. Size Price ($) Quantity Availability
A17037-14 25g 24.40
A17037-22 100g 58.00
A17037-36 500g 211.00
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CAPS, 99%

MDL
MFCD00003837
EINECS
214-492-1

Chemical Properties

Formula
C9H19NO3S
Formula Weight
221.32
Melting point
324°
Storage & Sensitivity
Ambient temperatures.
Solubility
Highly water soluble (100 g/L) at 20°C, and methanol (1%).

Applications

Used to formulate CAPS buffer, a zwitterionic buffer useful in the range of pH 7.9-11.1. CAPS buffer is widely used in Western and immunoblotting experiments as well as protein sequencing and identification. Used in the electro transfer of proteins to PVDF (sc-3723) or nitrocellulose membranes (sc-3718, sc-3724). The high pH of this buffer makes it useful for the transfer of proteins with a pI > 8.5. and minimal reactivity with enzymes or proteins, minimal salt effects.

Notes

Store away from oxidizing agents. Keep the container tightly sealed and store in cool, dry condition in well ventilated place.

Literature References

Jelena Zaitseva.; I Barry Holland.; Lutz Schmitt. The role of CAPS buffer in expanding the crystallization space of the nucleotide-binding domain of the ABC transporter haemolysin B from Escherichia coli.Acta Crystallogr D Biol Crystallogr.2004,60(6), 1076-1084.

Daniele de Sanctis.; Sylvia Dewilde.; Clemens Vonrhein.; Alessandra Pesce.; Luc Moens.; Paolo Ascenzi.; Thomas Hankeln.; Thorsten Burmester.; Marco Ponassi.; Marco Nardini.; Martino Bolognesi. Bishistidyl heme hexacoordination, a key structural property in Drosophila melanogaster hemoglobin.J Biol Chem.2005,280,(29), 27222-27229.

Buffer, pKa = 10.40 at 20o: Biochemistry, 5, 467 (1966).

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,1767
Beilstein
2835588
Harmonized Tariff Code
2921.30
TSCA
Yes
RTECS
TZ6395000

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