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Rose Bengal is a stain used in the eye drops to identify the eye damage. It finds application in the preparation of foraminifera for microscopic analysis, photosensitizing reactions and as a dye. In synthetic chemistry, it is utilized to convert triplet oxygen to singlet oxygen, which is used in [2+2] cycloadditions with alkenes. Its derivatives have important medical functions and used for the treatment of cancer. It acts as an alternative to phloxine B in Kreyberg's stain for keratin and mucus. As a fluorescent probe, it is used for the determination of NAD binding sites of alcohol dehydrogenase.
Yuan, K.; Wang, J.; Zhai, H.; Chen, Z.; Huang, L.; Su, Z. Sensitive determination of rose bengal in brown sugar by a molecularly imprinted solid-phase extraction monolithic capillary column coupled with capillary electrophoresis. Anal. Methods 2015, 7 (19), 8297-8303.
Lee, J. S.; Lee, B. I.; Park, C. B. Photo-induced inhibition of Alzheimer's beta-amyloid aggregation in vitro by rose bengal. Biomater. 2015, 38, 43-49.