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A17076 3-Bromo-5-iodobenzoic acid, 97%

CAS Number
188815-32-9
Synonyms

Stock No. Size Price ($) Quantity Availability
A17076-06 5g 49.20
A17076-14 25g 209.00
A17076-22 100g 685.00
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3-Bromo-5-iodobenzoic acid, 97%

MDL
MFCD00191851

Chemical Properties

Formula
C7H4BrIO2
Formula Weight
326.92
Melting point
218-221°
Storage & Sensitivity
Light Sensitive. Ambient temperatures.
Solubility
Soluble in methanol. Sparingly Soluble (0.20 g/L) (25°C), Calc.

Applications

3-Bromo-5-iodobenzoic acid may be used in the preparation of the following: • Phenyl(3-bromo-5-iodo)benzoate. • As starting reagent for the large-scale synthesis of the thromboxane receptor antagonist 3-{3-[2-(4-chlorobenzenesulfonamido)ethyl]-5-(4-fluorobenzyl)phenyl}propionic acid, via regioselective Heck cross-coupling reaction. • Methyl 3-bromo-5-iodobenzoate. • 3-Bromo-5-(triisopropylsilylethynyl)benzoic acid, via Sonogashira coupling reaction. • Trifluoroacetophenone.

Notes

Light Sensitive. Protect from light. Store away from oxidizing agents.

Literature References

Waite DC and Mason CP. A scalable synthesis of the thromboxane receptor antagonist 3-{3-[2-(4-chlorobenzenesulfonamido) ethyl]-5-(4-fluorobenzyl) phenyl} propionic acid via a regioselective Heck cross-coupling strategy.Org. Process Res. Dev.1998,2(2), 116-20.

S Lindman.; G Lindeberg.; F Nyberg.; A Karlén.; A Hallberg. Comparison of three gamma-turn mimetic scaffolds incorporated into angiotensin II.Bioorg Med Chem.2000,8,(9), 2375-2383.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
3240837
Harmonized Tariff Code
2916.39
TSCA
No

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