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A17129 4-Hydroxyquinazoline, 98%

CAS Number
491-36-1
Synonyms
4-Quinazolinol

Stock No. Size Price ($) Quantity Availability
A17129-09 10g 32.70
A17129-18 50g 106.00
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4-Hydroxyquinazoline, 98%

MDL
MFCD00511302
EINECS
207-735-8

Chemical Properties

Formula
C8H6N2O
Formula Weight
146.15
Melting point
216-219°
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM).

Applications

4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents.

Literature References

B Veres.; B Radnai.; F Gallyas.; G Varbiro. Regulation of Kinase Cascades and Transcription Factors by a Poly(ADP-Ribose) Polymerase-1 Inhibitor, 4-Hydroxyquinazoline, in Lipopolysaccharide-Induced Inflammation in Mice. JPET . 2004310 (1), 247-255.

JS Morley.; JCE Simpson. 88. The chemistry of simple heterocyclic systems. Part I. Reactions of 6-and 7-nitro-4-hydroxyquinazoline and their derivatives. Journal of the Chemical Society . 194888 (1), 360-366.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
118473
Harmonized Tariff Code
2933.59
TSCA
No
RTECS
VA2300000

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