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A17200 1-Naphthyl isocyanate, 98%

CAS Number
86-84-0
Synonyms

Stock No. Size Price ($) Quantity Availability
A17200-06 5g 42.00
A17200-14 25g 164.00
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1-Naphthyl isocyanate, 98%

MDL
MFCD00003881
EINECS
201-703-7

Chemical Properties

Formula
C11H7NO
Formula Weight
169.18
Melting point
Boiling Point
269°
Flash Point
135°(275°F)
Density
1.177
Refractive Index
1.6335
Storage & Sensitivity
Keep Cold. Moisture Sensitive.
Solubility
Miscible with alcohol, chloroform and diethyl ether.

Applications

1-Naphthyl isocyanate is used in the preparation of cationic aromatic urethane. It is useful for the study of cholangiolitic hepatotoxicity in laboratory animals. It is also employed as separate enantiomers of beta-blockers.

Notes

Moisture and light sensitive. Incompatible with strong oxidizing agents and alcohols.

Literature References

Belal, F.; Walash, M.; El-Enany, N.; Zayed, S. Highly sensitive HPLC method for assay of aliskiren in human plasma through derivatization with 1-naphthyl isocyanate using UV detection. J. Chromatogr. B 2013, 933, 24-29.

McEntyre, C. J.; Slow, S.; Lever, M. Measurement of plasma free choline by high performance liquid chromatography with fluorescence detection following derivatization with 1-naphthyl isocyanate. Anal. Chim. Acta 2009, 644 (1-2), 90-94.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H312-H315-H319-H332-H334-H335

Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation. Harmful if inhaled. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P285-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P342+P311-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. In case of inadequate ventilation wear respiratory protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,6410
Beilstein
742779
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2929.10
TSCA
Yes

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