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86-84-0 - 1-Naphthyl isocyanate, 98% - A17200 - Alfa Aesar

A17200 1-Naphthyl isocyanate, 98%

CAS Number
86-84-0
Synonyms

Size Price ($) Quantity Availability
5g 40.17
25g 147.60
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1-Naphthyl isocyanate, 98%

MDL
MFCD00003881
EINECS
201-703-7

Chemical Properties

Formula
C11H7NO
Formula Weight
169.18
Melting point
Boiling Point
269°
Flash Point
135°(275°F)
Density
1.177
Refractive Index
1.6335
Sensitivity
Moisture Sensitive
Solubility
Miscible with alcohol, chloroform and diethyl ether.

Applications

1-Naphthyl isocyanate is used in the preparation of cationic aromatic urethane. It is useful for the study of cholangiolitic hepatotoxicity in laboratory animals. It is also employed as separate enantiomers of beta-blockers.

Notes

Moisture and light sensitive. Incompatible with strong oxidizing agents and alcohols.

Literature References

Belal, F.; Walash, M.; El-Enany, N.; Zayed, S. Highly sensitive HPLC method for assay of aliskiren in human plasma through derivatization with 1-naphthyl isocyanate using UV detection. J. Chromatogr. B 2013, 933, 24-29.

McEntyre, C. J.; Slow, S.; Lever, M. Measurement of plasma free choline by high performance liquid chromatography with fluorescence detection following derivatization with 1-naphthyl isocyanate. Anal. Chim. Acta 2009, 644 (1-2), 90-94.

GHS Hazard and Precautionary Statements

Hazard Statements: H331-H315-H319-H335-H334

Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled.

Precautionary Statements: P260-P280h-P305+P351+P338-P309-P310

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER or doctor/physician.

Other References

Merck
14,6410
Beilstein
742779
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2929.10
TSCA
Yes

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