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1-Naphthyl isocyanate is used in the preparation of cationic aromatic urethane. It is useful for the study of cholangiolitic hepatotoxicity in laboratory animals. It is also employed as separate enantiomers of beta-blockers.
Belal, F.; Walash, M.; El-Enany, N.; Zayed, S. Highly sensitive HPLC method for assay of aliskiren in human plasma through derivatization with 1-naphthyl isocyanate using UV detection. J. Chromatogr. B 2013, 933, 24-29.
McEntyre, C. J.; Slow, S.; Lever, M. Measurement of plasma free choline by high performance liquid chromatography with fluorescence detection following derivatization with 1-naphthyl isocyanate. Anal. Chim. Acta 2009, 644 (1-2), 90-94.
Hazard Statements: H331-H315-H319-H334-H335
Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause respiratory irritation.
Precautionary Statements: P260-P280h-P305+P351+P338-P309-P310a
Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: