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1-Piperazineethanol is a hydroxyalkyl substituted pieprazine used in the preparation of pharmaceutical compounds. It is also used as an Intermediate in the manufacture of polyurethane catalysts, corrosion inhibitors, surfactants, synthetic fibers, pharmaceuticals. It is also used to synthesize triethylenediamine.
I Sircar.; SJ Haleen.; SE Burke. Synthesis and biological activity of 4-(diphenylmethyl)-. alpha.-[(4-quinolinyloxy) methyl]-1-piperazineethanol and related compounds. J. Med. Chem..199235 (23), 4442-4449.
HL Yale. Esters of 4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-1-piperazineethanol and related compounds as long-acting antipsychotic agents. Synthesis of the 1-adamantoate, the first crystalline base. 4 J. Med. Chem.197720 (2), 302-304.
Hazard Statements: H315-H318
Causes skin irritation. Causes serious eye damage.
Precautionary Statements: P280a-P264-P305+P351+P338-P310a-P321-P332+P313
Wear protective gloves and eye/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor Specific treatment (see label). If skin irritation occurs: Get medical advice/attention.