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Cresol red is commonly used with lead acetate for the detection of urease after PAGE. It is also used as an indicator with the following transition intervals: pH 1.8 (orange) to pH 2.0 (yellow); pH 7.0 (yellow) to pH 8.8 (violet). Cresol Red is used as a tracking dye in DNA, RNA (agarose) and protein (polyacrylamide) electrophoresis. In agarose, Cresol Red runs with an apparent molecular size of approx. 125 bp DNA. Cresol Red does not inhibit Taq polymerase.
Robert H. Byrne.; Jabe A. Breland. High precision multiwavelength pH determinations in seawater using cresol red. Deep Sea Research Part A. Oceanographic Research Papers. 1989, 36 (5), 803-810.
M. Neus Piña.; M. Carmen Rotger.; Antoni Costa.; Pablo Ballester.; Evaluation of anion selectivity in protic media by squaramide-Cresol Red ensembles. Pere M. Deyà. Tetrahedron Lett. 2004, 45 (19),3749-3752.
Acid-base indicator: pH 0.2 - 1.8; 7.0 - 8.8.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.