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123-99-9 - Azelaic acid, tech. 80% - Nonanedioic acid - A17271 - Alfa Aesar

A17271 Azelaic acid, tech. 80%

CAS Number
123-99-9
Synonyms
Nonanedioic acid

Size Price ($) Quantity Availability
500g 32.38
2500g 130.81
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Azelaic acid, tech. 80%

MDL
MFCD00004432
EINECS
204-669-1

Chemical Properties

Formula
HOOC(CH2)7COOH
Formula Weight
188.22
Melting point
ca 102°
Boiling Point
286°/100mm
Flash Point
215°(419°F)
Density
1.225
Solubility
Soluble in water at 20°C 2.4 g/L. Soluble in ethanol (5%), DMSO, methanol (70 mg/ml), and alcohol.

Applications

It is applied in organic synthesis, lacquers, polyester adhesives, and urethane elastomers. Azelaic acid directly inhibits kallikrein 5 (KLK5), down regulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases in vitro, in vivo, and in clinical settings. In PUFA-treated fibroblasts, azelaic acid decreases generation of ROS and up regulates expression of antioxidative enzymes, inhibiting cell damage; agonist activity at PPAR? is thought to drive these effects. Azelaic acid also inhibits proliferation of melanocytes. This compound displays antiacne and anticancer potential as well, inhibiting the proliferation of cutaneous melanoma due to suppression of mitochondrial oxidoreductive activity and DNA synthesis. It is a component of a number of hair and skin conditioners. Azelaic acid is used to treat mild to moderate acne, both comedonal acne and inflammatory acne. It is used in lubrication and plasticizers.

Notes

Store away from strong oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

M.R. Gasco, et al. In vitro permeation of azelaic acid from viscosized microemulsions.Int. J. Pharm.,1991,69(3), 193-196.

Graupe K, et al. Efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from European clinical trials and experimental reports.European Pubmed.,1996,57/span>(1), 20-35.

Other References

Merck
14,905
Beilstein
1101094
Harmonized Tariff Code
2917.13
TSCA
Yes
RTECS
CM1980000

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